| pubmed-article:20122818 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20122818 | lifeskim:mentions | umls-concept:C0687725 | lld:lifeskim |
| pubmed-article:20122818 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:20122818 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:20122818 | lifeskim:mentions | umls-concept:C1172779 | lld:lifeskim |
| pubmed-article:20122818 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:20122818 | pubmed:dateCreated | 2010-3-5 | lld:pubmed |
| pubmed-article:20122818 | pubmed:abstractText | The endogenous cannabinoid (EC) system has been recently implicated in several neuropsychiatric disorders. This study analyzed post-mortem brain regions of Cloninger type 1 (n=9) and 2 (n=8) alcoholics and non-alcoholic controls (n=10) for ECs by quantitative liquid chromatography with triple quadrupole mass spectrometric detection. A significant difference was found in anandamide (AEA) levels in nucleus accumbens (NAcc) between the three groups (p=0.047). AEA levels were significantly lower when compared to controls in both perigenual anterior cingulate (p=0.017) and frontal cortices (p=0.018) of type 1 alcoholics. Similar trends were observed for dihomo-gamma-linolenoyl ethanolamide and docosahexaenoyl ethanolamide, but not for 2-arachidonoylglycerol, palmitoyl ethanolamide, or oleoyl ethanolamide. Although preliminary, and from diagnostic groups with a relatively small number of subjects and substantially different mean ages for each group, these results suggest that the EC system may be hyperactive in type 2 alcoholics and hypoactive in type 1 alcoholics. | lld:pubmed |
| pubmed-article:20122818 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20122818 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20122818 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20122818 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20122818 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20122818 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:20122818 | pubmed:issn | 1873-7862 | lld:pubmed |
| pubmed-article:20122818 | pubmed:author | pubmed-author:CallawayJ CJC | lld:pubmed |
| pubmed-article:20122818 | pubmed:author | pubmed-author:TupalaErkkiE | lld:pubmed |
| pubmed-article:20122818 | pubmed:author | pubmed-author:TiihonenJariJ | lld:pubmed |
| pubmed-article:20122818 | pubmed:author | pubmed-author:HyytiäPetriP | lld:pubmed |
| pubmed-article:20122818 | pubmed:author | pubmed-author:LehtonenMarko... | lld:pubmed |
| pubmed-article:20122818 | pubmed:author | pubmed-author:StorvikMarkus... | lld:pubmed |
| pubmed-article:20122818 | pubmed:copyrightInfo | 2009 Elsevier B.V. and ECNP. All rights reserved. | lld:pubmed |
| pubmed-article:20122818 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20122818 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:20122818 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20122818 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20122818 | pubmed:pagination | 245-52 | lld:pubmed |
| pubmed-article:20122818 | pubmed:meshHeading | pubmed-meshheading:20122818... | lld:pubmed |
| pubmed-article:20122818 | pubmed:meshHeading | pubmed-meshheading:20122818... | lld:pubmed |
| pubmed-article:20122818 | pubmed:meshHeading | pubmed-meshheading:20122818... | lld:pubmed |
| pubmed-article:20122818 | pubmed:meshHeading | pubmed-meshheading:20122818... | lld:pubmed |
| pubmed-article:20122818 | pubmed:meshHeading | pubmed-meshheading:20122818... | lld:pubmed |
| pubmed-article:20122818 | pubmed:meshHeading | pubmed-meshheading:20122818... | lld:pubmed |
| pubmed-article:20122818 | pubmed:meshHeading | pubmed-meshheading:20122818... | lld:pubmed |
| pubmed-article:20122818 | pubmed:meshHeading | pubmed-meshheading:20122818... | lld:pubmed |
| pubmed-article:20122818 | pubmed:meshHeading | pubmed-meshheading:20122818... | lld:pubmed |
| pubmed-article:20122818 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20122818 | pubmed:articleTitle | Endogenous cannabinoids in post-mortem brains of Cloninger type 1 and 2 alcoholics. | lld:pubmed |
| pubmed-article:20122818 | pubmed:affiliation | Department of Pharmaceutical Chemistry, University of Kuopio, P.O. Box 1627, FI-70211 Kuopio, Finland. | lld:pubmed |
| pubmed-article:20122818 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20122818 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:20122818 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
