| pubmed-article:20118768 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20118768 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:20118768 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:20118768 | lifeskim:mentions | umls-concept:C0001430 | lld:lifeskim |
| pubmed-article:20118768 | lifeskim:mentions | umls-concept:C1266025 | lld:lifeskim |
| pubmed-article:20118768 | lifeskim:mentions | umls-concept:C0205462 | lld:lifeskim |
| pubmed-article:20118768 | lifeskim:mentions | umls-concept:C0205348 | lld:lifeskim |
| pubmed-article:20118768 | lifeskim:mentions | umls-concept:C0439858 | lld:lifeskim |
| pubmed-article:20118768 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:20118768 | pubmed:dateCreated | 2010-3-1 | lld:pubmed |
| pubmed-article:20118768 | pubmed:abstractText | We have recently shown that a study population of patients with at least 1 sessile serrated adenoma (SSA) are 4 times more likely to harbor synchronous serrated polyps [SSAs, traditional serrated adenomas (TSAs) and right sided hyperplastic polyps] than a unselected population of patients. However, 35% of the polyps in the study patients were conventional adenomas (CAds). We hypothesized that the CAds in these study patients would have histologic and molecular differences compared with CAds from a control population without sessile serrated adenomas. To this end, 104 study and 79 control CAds were analyzed according to 9 histologic criteria. A subset of these polyps was also screened for BRAF mutations, KRAS mutations, CpG island methylation, and MUC6 expression. A total of 31 study CAds and 2 control CAds had atypical histologic features (bright cytoplasmic eosinophilia +/- focal serrations and crypt dilatation). None of the adenomas tested had mutations in BRAF or KRAS. Evidence of low levels of CpG island methylation was seen in 35% of the atypical CAds and in only 4.5% of the typical CAds. In addition, these atypical CAds were more likely to express MUC6. Thus, the presence of cytoplasmic eosinophilia with or without focal serrations and crypt dilatation identifies a subset of CAds with characteristics of the serrated neoplasia pathway. These atypical CAds occur more commonly in patients predisposed to developing SSAs and suggest the presence of a mucosal field defect in these patients. | lld:pubmed |
| pubmed-article:20118768 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20118768 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20118768 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:20118768 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20118768 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:20118768 | pubmed:issn | 1532-0979 | lld:pubmed |
| pubmed-article:20118768 | pubmed:author | pubmed-author:HartJohnJ | lld:pubmed |
| pubmed-article:20118768 | pubmed:author | pubmed-author:NoffsingerAmy... | lld:pubmed |
| pubmed-article:20118768 | pubmed:author | pubmed-author:PaiRish KRK | lld:pubmed |
| pubmed-article:20118768 | pubmed:author | pubmed-author:JosephLorenL | lld:pubmed |
| pubmed-article:20118768 | pubmed:author | pubmed-author:MackinnonAlex... | lld:pubmed |
| pubmed-article:20118768 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20118768 | pubmed:volume | 34 | lld:pubmed |
| pubmed-article:20118768 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20118768 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20118768 | pubmed:pagination | 355-63 | lld:pubmed |
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| pubmed-article:20118768 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20118768 | pubmed:articleTitle | Identification of histologically distinct conventional adenomas that arise predominately in patients with sessile serrated adenomas. | lld:pubmed |
| pubmed-article:20118768 | pubmed:affiliation | Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110-1093, USA. rpai@path.wustl.edu | lld:pubmed |
| pubmed-article:20118768 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20118768 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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