Linked Life Data

20118768

Source:http://linkedlifedata.com/resource/pubmed/id/20118768

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2010-3-1
pubmed:abstractText
We have recently shown that a study population of patients with at least 1 sessile serrated adenoma (SSA) are 4 times more likely to harbor synchronous serrated polyps [SSAs, traditional serrated adenomas (TSAs) and right sided hyperplastic polyps] than a unselected population of patients. However, 35% of the polyps in the study patients were conventional adenomas (CAds). We hypothesized that the CAds in these study patients would have histologic and molecular differences compared with CAds from a control population without sessile serrated adenomas. To this end, 104 study and 79 control CAds were analyzed according to 9 histologic criteria. A subset of these polyps was also screened for BRAF mutations, KRAS mutations, CpG island methylation, and MUC6 expression. A total of 31 study CAds and 2 control CAds had atypical histologic features (bright cytoplasmic eosinophilia +/- focal serrations and crypt dilatation). None of the adenomas tested had mutations in BRAF or KRAS. Evidence of low levels of CpG island methylation was seen in 35% of the atypical CAds and in only 4.5% of the typical CAds. In addition, these atypical CAds were more likely to express MUC6. Thus, the presence of cytoplasmic eosinophilia with or without focal serrations and crypt dilatation identifies a subset of CAds with characteristics of the serrated neoplasia pathway. These atypical CAds occur more commonly in patients predisposed to developing SSAs and suggest the presence of a mucosal field defect in these patients.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1532-0979
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
355-63
pubmed:meshHeading
pubmed-meshheading:20118768-Adenoma, pubmed-meshheading:20118768-Aged, pubmed-meshheading:20118768-Case-Control Studies, pubmed-meshheading:20118768-Colonic Neoplasms, pubmed-meshheading:20118768-Colonic Polyps, pubmed-meshheading:20118768-CpG Islands, pubmed-meshheading:20118768-DNA Methylation, pubmed-meshheading:20118768-DNA Mutational Analysis, pubmed-meshheading:20118768-Dilatation, Pathologic, pubmed-meshheading:20118768-Eosinophilia, pubmed-meshheading:20118768-Female, pubmed-meshheading:20118768-Gene Expression Regulation, Neoplastic, pubmed-meshheading:20118768-Humans, pubmed-meshheading:20118768-Hyperplasia, pubmed-meshheading:20118768-Immunohistochemistry, pubmed-meshheading:20118768-Intestinal Mucosa, pubmed-meshheading:20118768-Male, pubmed-meshheading:20118768-Middle Aged, pubmed-meshheading:20118768-Mucin-6, pubmed-meshheading:20118768-Mutation, pubmed-meshheading:20118768-Precancerous Conditions, pubmed-meshheading:20118768-Proto-Oncogene Proteins, pubmed-meshheading:20118768-Proto-Oncogene Proteins B-raf, pubmed-meshheading:20118768-ras Proteins
pubmed:year
2010
pubmed:articleTitle
Identification of histologically distinct conventional adenomas that arise predominately in patients with sessile serrated adenomas.
pubmed:affiliation
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110-1093, USA. rpai@path.wustl.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't