The TIM23 complex in the inner membrane of mitochondria mediates import of essentially all matrix proteins and a large number of inner membrane proteins. Here we present an overview on the latest insights into the structure and function of this remarkable molecular machine.
Institute for Physiological Chemistry and Munich Center for Integrated Protein Science CIPSM, Ludwig-Maximilians University, Butenandtstr. 5, 81377 Munich, Germany. dejana.mokranjac@med.uni-muenchen.de