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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2010-1-29
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pubmed:abstractText |
Alpha-1-antitrypsin (AAT) is a serine protease inhibitor that blocks the protease, neutrophil elastase. Previous population studies have suggested that heterozygote status for the AAT gene (SERPINA1) is a risk factor for chronic rhinosinusitis with nasal polyposis (CRSwNP). This implies a potential genetic predisposition to CRS tied to AAT deficiency. The purpose of this study was to investigate the association between single nucleotide polymorphisms (SNPs) in the SERPINA1 gene and CRS.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1945-8932
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e4-9
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pubmed:dateRevised |
2011-11-10
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pubmed:meshHeading |
pubmed-meshheading:20109307-Adult,
pubmed-meshheading:20109307-Aged,
pubmed-meshheading:20109307-Chronic Disease,
pubmed-meshheading:20109307-DNA Mutational Analysis,
pubmed-meshheading:20109307-Disease Progression,
pubmed-meshheading:20109307-Drug Resistance,
pubmed-meshheading:20109307-Female,
pubmed-meshheading:20109307-Gene Frequency,
pubmed-meshheading:20109307-Genetic Association Studies,
pubmed-meshheading:20109307-Genetic Predisposition to Disease,
pubmed-meshheading:20109307-Humans,
pubmed-meshheading:20109307-Male,
pubmed-meshheading:20109307-Middle Aged,
pubmed-meshheading:20109307-Nasal Polyps,
pubmed-meshheading:20109307-Polymorphism, Single Nucleotide,
pubmed-meshheading:20109307-Rhinitis,
pubmed-meshheading:20109307-Sinusitis,
pubmed-meshheading:20109307-alpha 1-Antitrypsin
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pubmed:articleTitle |
Polymorphisms in the SERPINA1 (Alpha-1-Antitrypsin) gene are associated with severe chronic rhinosinusitis unresponsive to medical therapy.
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pubmed:affiliation |
The Department of Otolaryngology, Hôpital Hôtel-Dieu de Montréal, Université de Montréal, Montreal, Quebec, Canada. shaunkilty@hotmail.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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