| pubmed-article:20109102 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20109102 | lifeskim:mentions | umls-concept:C0010097 | lld:lifeskim |
| pubmed-article:20109102 | lifeskim:mentions | umls-concept:C0162512 | lld:lifeskim |
| pubmed-article:20109102 | lifeskim:mentions | umls-concept:C0025462 | lld:lifeskim |
| pubmed-article:20109102 | lifeskim:mentions | umls-concept:C0108685 | lld:lifeskim |
| pubmed-article:20109102 | lifeskim:mentions | umls-concept:C0332293 | lld:lifeskim |
| pubmed-article:20109102 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:20109102 | lifeskim:mentions | umls-concept:C1512488 | lld:lifeskim |
| pubmed-article:20109102 | lifeskim:mentions | umls-concept:C1515926 | lld:lifeskim |
| pubmed-article:20109102 | lifeskim:mentions | umls-concept:C0061421 | lld:lifeskim |
| pubmed-article:20109102 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:20109102 | pubmed:dateCreated | 2010-3-10 | lld:pubmed |
| pubmed-article:20109102 | pubmed:abstractText | The present study performed proteomic analysis of the midbrain and striatum of 6-hydroxydopamine (6-OHDA)-treated neonatal rats--a model of attention-deficit hyperactivity disorder (ADHD). Proteomic analysis revealed that a 58-kDa glucose-regulated protein (Grp58) was temporarily phosphorylated and its level was elevated by 6-OHDA. Furthermore, 6-OHDA increased the expression level of C/EBP homologous protein (CHOP), a mediator of endoplasmic reticulum (ER) stress response, in the midbrain and striatum. In vitro experiments using PC12 cells revealed that 6-OHDA or hydrogen peroxide could induce the elevation of Grp58 and CHOP. 6-OHDA could induce the elevation of Grp58 and CHOP in the presence of catalase, a hydrogen peroxide-removing enzyme, suggesting that the elevation of Grp58 and CHOP are induced by both hydrogen peroxide and p-quinone generated by 6-OHDA. Collectively, these findings suggest that ER stress involving the alteration of Grp58 and CHOP play a significant role in the induction of insults by 6-OHDA in vivo. | lld:pubmed |
| pubmed-article:20109102 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20109102 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20109102 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20109102 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20109102 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20109102 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20109102 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20109102 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20109102 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20109102 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20109102 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20109102 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20109102 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20109102 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20109102 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:20109102 | pubmed:issn | 1029-2470 | lld:pubmed |
| pubmed-article:20109102 | pubmed:author | pubmed-author:NikiEtsuoE | lld:pubmed |
| pubmed-article:20109102 | pubmed:author | pubmed-author:SaitoYoshiroY | lld:pubmed |
| pubmed-article:20109102 | pubmed:author | pubmed-author:AshidaHitoshi... | lld:pubmed |
| pubmed-article:20109102 | pubmed:author | pubmed-author:MasuoYoshinor... | lld:pubmed |
| pubmed-article:20109102 | pubmed:author | pubmed-author:YoshidaYasuka... | lld:pubmed |
| pubmed-article:20109102 | pubmed:author | pubmed-author:NishioKeikoK | lld:pubmed |
| pubmed-article:20109102 | pubmed:author | pubmed-author:KinumiTomoyaT | lld:pubmed |
| pubmed-article:20109102 | pubmed:author | pubmed-author:HorieMasanori... | lld:pubmed |
| pubmed-article:20109102 | pubmed:author | pubmed-author:AkazawaYoko... | lld:pubmed |
| pubmed-article:20109102 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20109102 | pubmed:volume | 44 | lld:pubmed |
| pubmed-article:20109102 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20109102 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20109102 | pubmed:pagination | 410-21 | lld:pubmed |
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| pubmed-article:20109102 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20109102 | pubmed:articleTitle | Proteomic characterization of the striatum and midbrain treated with 6-hydroxydopamine: alteration of 58-kDa glucose-regulated protein and C/EBP homologous protein. | lld:pubmed |
| pubmed-article:20109102 | pubmed:affiliation | Health Technology Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Kansai Center, Ikeda, Osaka, Japan. | lld:pubmed |
| pubmed-article:20109102 | pubmed:publicationType | Journal Article | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:20109102 | lld:pubmed |
