Linked Life Data

20108925

Source:http://linkedlifedata.com/resource/pubmed/id/20108925

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2010-3-1
pubmed:abstractText
Amperometric detection at microelectrodes in lab-on-a-chip (LOAC) devices lose advantages in signal-to-background ratio, reduced ohmic iR drop, and steady-state signal when volumes are so small that diffusion fields reach the walls before flux becomes fully radial. Redox cycling of electroactive species between multiple, closely spaced microelectrodes offsets that limitation and provides amplification capabilities. A device that integrates a microchannel with an individually addressable microband electrode array has been used to study effects of signal amplification due to redox cycling in a confined, static solution with different configurations and numbers of active generators and collectors. The microfabricated device consists of a 22 microm high, 600 microm wide microchannel containing an array of 50 microm wide, 600 microm long gold microbands, separated by 25 microm gaps, interspersed with an 800 microm wide counter electrode and 400 microm wide passive conductor, with a distant but on-chip 400 microm wide pseudoreference electrode. Investigations involve solutions of potassium chloride electrolyte containing potassium ferrocyanide. Amplification factors were as high as 7.60, even with these microelectrodes of fairly large dimensions (which are generally less expensive, easier, and more reproducible to fabricate), because of the significant role that passive and active (instrumentally induced) redox cycling plays in confined volumes of enclosed microchannels. The studies are useful in optimizing designs for LOAC devices.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/20108925-10999634, http://linkedlifedata.com/resource/pubmed/commentcorrection/20108925-11708116, http://linkedlifedata.com/resource/pubmed/commentcorrection/20108925-12139035, http://linkedlifedata.com/resource/pubmed/commentcorrection/20108925-12720345, http://linkedlifedata.com/resource/pubmed/commentcorrection/20108925-15100857, http://linkedlifedata.com/resource/pubmed/commentcorrection/20108925-15144178, http://linkedlifedata.com/resource/pubmed/commentcorrection/20108925-15522606, http://linkedlifedata.com/resource/pubmed/commentcorrection/20108925-16511625, http://linkedlifedata.com/resource/pubmed/commentcorrection/20108925-17073411, http://linkedlifedata.com/resource/pubmed/commentcorrection/20108925-17298005, http://linkedlifedata.com/resource/pubmed/commentcorrection/20108925-18193890, http://linkedlifedata.com/resource/pubmed/commentcorrection/20108925-18970340
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1520-6882
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
82
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1659-68
pubmed:dateRevised
2011-7-25
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Signal amplification in a microchannel from redox cycling with varied electroactive configurations of an individually addressable microband electrode array.
pubmed:affiliation
Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, Arkansas 72701, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural