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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2010-5-20
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pubmed:abstractText |
Glaucoma is a neurodegenerative disease in which elevated intraocular pressure (IOP) leads to progressive loss of retinal ganglion cells (RGCs) and blindness. Calcium dyshomeostasis has been suggested to play a role in the pathologic events that lead to RGC loss, though the details of these events are not well understood. Calcium-induced activation of calpain has been shown to contribute to neuronal death in a wide variety of neurodegenerative diseases. The authors hypothesize that similar events occur in glaucoma.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1552-5783
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3049-54
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pubmed:dateRevised |
2011-3-3
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pubmed:meshHeading |
pubmed-meshheading:20107181-Animals,
pubmed-meshheading:20107181-Blotting, Western,
pubmed-meshheading:20107181-Calcinosis,
pubmed-meshheading:20107181-Calpain,
pubmed-meshheading:20107181-Disease Models, Animal,
pubmed-meshheading:20107181-Enzyme Activation,
pubmed-meshheading:20107181-Glaucoma,
pubmed-meshheading:20107181-Immunoenzyme Techniques,
pubmed-meshheading:20107181-Immunoprecipitation,
pubmed-meshheading:20107181-Intraocular Pressure,
pubmed-meshheading:20107181-Male,
pubmed-meshheading:20107181-Proteomics,
pubmed-meshheading:20107181-Rats,
pubmed-meshheading:20107181-Rats, Inbred BN,
pubmed-meshheading:20107181-Retinal Ganglion Cells,
pubmed-meshheading:20107181-Spectrin,
pubmed-meshheading:20107181-Spectrometry, Mass, Matrix-Assisted Laser...
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pubmed:year |
2010
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pubmed:articleTitle |
Calpain activation in experimental glaucoma.
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pubmed:affiliation |
Howe Laboratory of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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