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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2010-4-22
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pubmed:abstractText |
The maturation of antigen-presenting dendritic cells (DCs) serves as an important determinant for the regulation of immunity, and overall immune response. We hypothesized that a reduced immune response to donor alloantigens and improved allograft survival could be induced by pre-treating recipients with bone-marrow-derived donor-strain fixed immature DCs (FIDCs). Donor-strain-derived mature and immature DCs were fixed before grafting to ensure that they possessed a stable immunogenic phenotype. The fixed mature DCs effectively induced allogeneic T-cell proliferation in recipients, whereas FIDCs were unable to elicit an allogeneic T-cell response. T cells that had previously been exposed to FIDCs maintained naïve phenotypes and were unable to extensively divide after injection into lethally irradiated donor-strain mice. The pre-treatment of recipients with donor-strain FIDCs markedly prolonged the survival of islet as well as skin allografts. However, T-cell hyporesponsiveness induced by FIDC injection was abrogated by the depletion of CD4(+) CD25(+) T cells. Consequently, FIDC-induced T-cell hyporesponsiveness could reflect anergy rather than specific deletion. Our findings suggest that FIDCs of donor strain could be used to induce long-term graft survival.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20102412-10593509,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20102412-10605007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20102412-10662786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20102412-10807783,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20102412-10940870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20102412-11145675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20102412-11489974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20102412-11672590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20102412-11751957,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20102412-12218160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20102412-12391020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20102412-12413527,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20102412-12530984,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20102412-12615891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20102412-12727648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20102412-12750162,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20102412-12753738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20102412-12874257,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20102412-12974778,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20102412-139445,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20102412-14670304,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20102412-14702533,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20102412-14712275,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20102412-15036233,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20102412-15122249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20102412-15516925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20102412-15567925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20102412-16244650,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20102412-16365425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20102412-16952297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20102412-19208362,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20102412-233898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20102412-6239901,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20102412-7602120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20102412-8544435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20102412-8587280,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20102412-9285405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20102412-9399965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20102412-9846510
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1365-2567
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
129
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
567-77
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pubmed:dateRevised |
2011-7-27
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pubmed:meshHeading |
pubmed-meshheading:20102412-Animals,
pubmed-meshheading:20102412-Bone Marrow Cells,
pubmed-meshheading:20102412-Cell Proliferation,
pubmed-meshheading:20102412-Dendritic Cells,
pubmed-meshheading:20102412-Female,
pubmed-meshheading:20102412-Formaldehyde,
pubmed-meshheading:20102412-Graft Survival,
pubmed-meshheading:20102412-H-2 Antigens,
pubmed-meshheading:20102412-Isoantigens,
pubmed-meshheading:20102412-Mice,
pubmed-meshheading:20102412-Mice, Inbred BALB C,
pubmed-meshheading:20102412-Mice, Inbred C3H,
pubmed-meshheading:20102412-Mice, Inbred C57BL,
pubmed-meshheading:20102412-Mice, Inbred DBA,
pubmed-meshheading:20102412-Mice, Transgenic,
pubmed-meshheading:20102412-Phenotype,
pubmed-meshheading:20102412-T-Lymphocytes, Regulatory,
pubmed-meshheading:20102412-Tissue Donors,
pubmed-meshheading:20102412-Tissue Fixation,
pubmed-meshheading:20102412-Transplantation, Homologous,
pubmed-meshheading:20102412-Transplantation Tolerance
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pubmed:year |
2010
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pubmed:articleTitle |
Donor-strain-derived immature dendritic cell pre-treatment induced hyporesponsiveness against allogeneic antigens.
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pubmed:affiliation |
Kidney Research Institute, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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