Source:http://linkedlifedata.com/resource/pubmed/id/20097080
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2010-2-17
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pubmed:abstractText |
As one of our ongoing research project concerning development of a novel anti-influenza virus agent, dihydrofuran-fused perhydrophenanthrenes were derivatized by means of Williamson ether synthesis and Suzuki-Miyaura cross coupling reactions. Newly synthesized compounds were subjected to evaluation of anti-influenza virus activity using influenza A/Aichi/2/68 (H3N2 subtype) virus strain by a plaque titration method. These investigations revealed that incorporation of benzyl-type ether substituents was effective for exerting the inhibition activity of influenza virus proliferation.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1464-3391
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pubmed:author | |
pubmed:copyrightInfo |
Copyright 2010 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1477-81
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pubmed:meshHeading |
pubmed-meshheading:20097080-Animals,
pubmed-meshheading:20097080-Antiviral Agents,
pubmed-meshheading:20097080-Cells, Cultured,
pubmed-meshheading:20097080-Dogs,
pubmed-meshheading:20097080-Furans,
pubmed-meshheading:20097080-Influenza A Virus, H3N2 Subtype,
pubmed-meshheading:20097080-Magnetic Resonance Spectroscopy,
pubmed-meshheading:20097080-Mass Spectrometry,
pubmed-meshheading:20097080-Phenanthrenes,
pubmed-meshheading:20097080-Spectroscopy, Fourier Transform Infrared
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pubmed:year |
2010
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pubmed:articleTitle |
Synthesis and anti-influenza virus activity of dihydrofuran-fused perhydrophenanthrenes with a benzyloxy-type side-chain.
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pubmed:affiliation |
Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan. matsuya@pha.u-toyama.ac.jp
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pubmed:publicationType |
Journal Article
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