Linked Life Data

20077430

Source:http://linkedlifedata.com/resource/pubmed/id/20077430

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2010-4-8
pubmed:abstractText
By using two different approaches, ubiquitin C-terminal hydrolase 1 (UCHL1) was identified as a potential cerebrospinal fluid (CSF) biomarker of neuronal loss in aneurysmal subarachnoid hemorrhage (ASAH) and presumably other CNS damage and disease states. Appropriate antibodies and a sensitive ELISA were generated, and the release of UCHL1 into CSF was compared with that of pNF-H and S100beta in a cohort of 30 ASAH patients. Both UCHL1 and pNF-H showed persistent release into CSF in almost all patients in the second week postaneurysmal rupture (AR), and S100beta levels rapidly declined to baseline levels in 23 of 30 patients. Seven of thirty patients showed persistently elevated S100beta levels over the first 5 days post-AR and also had relatively higher levels of pNF-H and UCHL1 higher compared with the rest. These patients proved to have very poor outcomes, with 6 of 7 expiring. Patients who did reduce S100beta levels tended to have a better outcome if pNF-H and UCHL1 levels were also lower, and elevated UCHL1 levels in the second week post-AR were particularly predictive of poor outcome. Acute coordinated releases of large amounts of UCHL1, pNF-H, and S100beta in 16 of 30 patients were observed, suggesting sudden loss of brain tissues associated with secondary events. We conclude that measurement of the CSF levels of these proteins reveals details of ASAH progression and recovery and predicts patient outcome.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1097-4547
pubmed:author
pubmed:copyrightInfo
(c) 2010 Wiley-Liss, Inc.
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
88
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1475-84
pubmed:meshHeading
pubmed-meshheading:20077430-Adult, pubmed-meshheading:20077430-Aged, pubmed-meshheading:20077430-Aged, 80 and over, pubmed-meshheading:20077430-Biological Markers, pubmed-meshheading:20077430-Brain Infarction, pubmed-meshheading:20077430-Cohort Studies, pubmed-meshheading:20077430-Enzyme-Linked Immunosorbent Assay, pubmed-meshheading:20077430-Female, pubmed-meshheading:20077430-Humans, pubmed-meshheading:20077430-Male, pubmed-meshheading:20077430-Middle Aged, pubmed-meshheading:20077430-Nerve Degeneration, pubmed-meshheading:20077430-Nerve Growth Factors, pubmed-meshheading:20077430-Neurofilament Proteins, pubmed-meshheading:20077430-Neurons, pubmed-meshheading:20077430-Predictive Value of Tests, pubmed-meshheading:20077430-Prognosis, pubmed-meshheading:20077430-S100 Proteins, pubmed-meshheading:20077430-Subarachnoid Hemorrhage, pubmed-meshheading:20077430-Ubiquitin Thiolesterase, pubmed-meshheading:20077430-Up-Regulation
pubmed:year
2010
pubmed:articleTitle
Identification and preliminary characterization of ubiquitin C terminal hydrolase 1 (UCHL1) as a biomarker of neuronal loss in aneurysmal subarachnoid hemorrhage.
pubmed:affiliation
Department of Neurological Surgery, McKnight Brain Institute, University of Florida College of Medicine, Gainesville, FL 32610, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural