Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1978-1-27
|
| pubmed:abstractText |
Surface, needle and micro-electrode recordings were obtained from sensory nerves of patients with various types of peripheral neuropathy. Changes in amplitude and conduction velocity of nerve action potentials were measured after a single conditioning stimulus and after tetanic stimulation for 2 min. In patients with hereditary forms of axonal degeneration (AD), recovery processes of nerve fibres of all conduction velocities were normal; in acquired forms of AD fibres with conduction velocity less than 30 m/sec had greater and more prolonged post-tetanic depression than control nerves of similar conduction velocity. Where neuropathy was associated with segmental demyelination (SD), fibres of all conduction velocities had prolonged recovery processes after both single and tetanic stimulation. The changes were especially marked at higher skin temperature, and were greater than the changes seen in nerves with acquired forms of AD. Finally, 2 sural nerves were studied during the process of Wallerian degeneration after a biopsy had been obtained proximally, and recovery processes did not change during the period of degeneration. Perceptual abnormalities were similar in AD and SD. It is suggested that changes in recovery processes of nerve fibres with segmental demyelination or regeneration after injury contribute to the perceptual abnormalities which occur in clinically encountered peripheral neuropathies.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0022-510X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
34
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
175-89
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:200718-Action Potentials,
pubmed-meshheading:200718-Charcot-Marie-Tooth Disease,
pubmed-meshheading:200718-Demyelinating Diseases,
pubmed-meshheading:200718-Electric Stimulation,
pubmed-meshheading:200718-Humans,
pubmed-meshheading:200718-Nerve Degeneration,
pubmed-meshheading:200718-Neural Conduction,
pubmed-meshheading:200718-Peripheral Nerves,
pubmed-meshheading:200718-Peripheral Nervous System Diseases,
pubmed-meshheading:200718-Refractory Period, Electrophysiological,
pubmed-meshheading:200718-Sensation,
pubmed-meshheading:200718-Skin Temperature,
pubmed-meshheading:200718-Wallerian Degeneration
|
| pubmed:year |
1977
|
| pubmed:articleTitle |
A micro-electrode study of peripheral neuropathy in man. Part 2. Responses to conditioning stimuli.
|
| pubmed:publicationType |
Journal Article
|