Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2010-9-8
pubmed:abstractText
Acute GVHD has remained a significant cause of nonrelapse mortality after allogeneic hematopoietic cell transplantation (HCT) with nonmyeloablative conditioning. The role of TNF-alpha in the biology of acute GVHD after nonmyeloablative conditioning has not been studied thus far. Here, we measured TNF receptor 1 (TNFR1) as a surrogate marker for TNF-alpha in 106 patients before the start of the conditioning regimen (baseline) and 7 days after allogeneic HCT with nonmyeloablative conditioning. The nonmyeloablative regimen consisted of 2 Gy TBI alone (n=15), 2 Gy TBI plus fludarabine 90 mg/m2 (n=73), or 4 Gy TBI plus fludarabine 90 mg/m2 (n=18). TNFR1 levels increased significantly from baseline to day 7 after nonmyeloablative HCT (P<0.0001). Patients conditioned with 4 Gy TBI had higher TNFR1 day 7/baseline ratio than those conditioned with 2 Gy TBI (median 1.65 versus 1.25; P=0.01). In a multivariate Cox model, high TNFR1 day7/baseline ratio was associated with grades II-IV (HR=2.2, P=0.01) and grades III-IV (HR=2.9, P=0.007) acute GVHD, but had no impact on overall survival (P=0.8). In summary, our data suggest that nonmyeloablative conditioning induces the generation of TNF-alpha, and that the magnitude of TNF-alpha generation depends on the conditioning intensity (2 Gy versus 4 Gy TBI). Further, assessment of TNFR1 levels before and on day 7 after nonmyeloablative HCT provided useful information on subsequent risk of experiencing acute GVHD.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1476-5365
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1442-8
pubmed:meshHeading
pubmed-meshheading:20062090-Acute Disease, pubmed-meshheading:20062090-Adolescent, pubmed-meshheading:20062090-Adult, pubmed-meshheading:20062090-Aged, pubmed-meshheading:20062090-Child, pubmed-meshheading:20062090-Cohort Studies, pubmed-meshheading:20062090-Female, pubmed-meshheading:20062090-Graft vs Host Disease, pubmed-meshheading:20062090-Hematologic Diseases, pubmed-meshheading:20062090-Hematopoietic Stem Cell Transplantation, pubmed-meshheading:20062090-Humans, pubmed-meshheading:20062090-Male, pubmed-meshheading:20062090-Middle Aged, pubmed-meshheading:20062090-Receptors, Tumor Necrosis Factor, Type I, pubmed-meshheading:20062090-Recurrence, pubmed-meshheading:20062090-Ribosomal Proteins, pubmed-meshheading:20062090-Risk Factors, pubmed-meshheading:20062090-Transplantation, Homologous, pubmed-meshheading:20062090-Transplantation Chimera, pubmed-meshheading:20062090-Transplantation Conditioning, pubmed-meshheading:20062090-Young Adult
pubmed:year
2010
pubmed:articleTitle
Elevations of tumor necrosis factor receptor 1 at day 7 and acute graft-versus-host disease after allogeneic hematopoietic cell transplantation with nonmyeloablative conditioning.
pubmed:affiliation
Division of Hematology, Department of Medicine, CHU of Liége, Liége, Belgium.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't