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pubmed-article:20056134pubmed:abstractTextEpidemiological and experimental evidence that support the correlation between Type 2 diabetes mellitus (T2D) and increased risks of colorectal cancer formation have led us to hypothesize the existence of molecular crosstalk between insulin and canonical Wnt signaling pathways. Insulin was shown to stimulate Wnt target gene expression, utilizing the effector of the Wnt signaling pathway. Whether insulin affects expression of components of Wnt pathway has not been extensively examined.lld:pubmed
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pubmed-article:20056134pubmed:copyrightInfoCopyright (c) 2009 Elsevier B.V. All rights reserved.lld:pubmed
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pubmed-article:20056134pubmed:pagination344-51lld:pubmed
pubmed-article:20056134pubmed:dateRevised2011-11-17lld:pubmed
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pubmed-article:20056134pubmed:articleTitleInsulin alters the expression of components of the Wnt signaling pathway including TCF-4 in the intestinal cells.lld:pubmed
pubmed-article:20056134pubmed:affiliationDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Canada; Division of Cell and Molecular Biology, University Health Network, Canada.lld:pubmed
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