rdf:type |
|
lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0021641,
umls-concept:C0185117,
umls-concept:C0332257,
umls-concept:C0449432,
umls-concept:C0814997,
umls-concept:C1179435,
umls-concept:C1420644,
umls-concept:C1520113,
umls-concept:C1524073,
umls-concept:C1548799,
umls-concept:C1705000,
umls-concept:C1705248,
umls-concept:C2911684
|
pubmed:issue |
3
|
pubmed:dateCreated |
2010-2-22
|
pubmed:abstractText |
Epidemiological and experimental evidence that support the correlation between Type 2 diabetes mellitus (T2D) and increased risks of colorectal cancer formation have led us to hypothesize the existence of molecular crosstalk between insulin and canonical Wnt signaling pathways. Insulin was shown to stimulate Wnt target gene expression, utilizing the effector of the Wnt signaling pathway. Whether insulin affects expression of components of Wnt pathway has not been extensively examined.
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pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Basic Helix-Loop-Helix Leucine...,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/TCF4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Tcf4 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt Proteins
|
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
|
pubmed:issn |
0006-3002
|
pubmed:author |
|
pubmed:copyrightInfo |
Copyright (c) 2009 Elsevier B.V. All rights reserved.
|
pubmed:issnType |
Print
|
pubmed:volume |
1800
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
344-51
|
pubmed:dateRevised |
2011-11-17
|
pubmed:meshHeading |
pubmed-meshheading:20056134-Animals,
pubmed-meshheading:20056134-Basic Helix-Loop-Helix Leucine Zipper Transcription Factors,
pubmed-meshheading:20056134-Cell Line,
pubmed-meshheading:20056134-DNA, Complementary,
pubmed-meshheading:20056134-DNA Primers,
pubmed-meshheading:20056134-DNA-Binding Proteins,
pubmed-meshheading:20056134-Gene Expression Regulation,
pubmed-meshheading:20056134-HT29 Cells,
pubmed-meshheading:20056134-Humans,
pubmed-meshheading:20056134-Insulin,
pubmed-meshheading:20056134-Intestines,
pubmed-meshheading:20056134-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:20056134-Polymerase Chain Reaction,
pubmed-meshheading:20056134-Rats,
pubmed-meshheading:20056134-Transcription Factors,
pubmed-meshheading:20056134-Wnt Proteins
|
pubmed:year |
2010
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pubmed:articleTitle |
Insulin alters the expression of components of the Wnt signaling pathway including TCF-4 in the intestinal cells.
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pubmed:affiliation |
Department of Laboratory Medicine and Pathobiology, University of Toronto, Canada; Division of Cell and Molecular Biology, University Health Network, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|