Source:http://linkedlifedata.com/resource/pubmed/id/20053349
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2010-3-8
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| pubmed:abstractText |
The weak androgen oxandrolone (Ox) increases height gain in growth-hormone (GH) treated girls with Turner syndrome (TS), but may also give rise to virilizing side effects. To assess the effect of Ox, at a conventional and low dosage, on behavior, aggression, romantic and sexual interest, mood, and gender role in GH-treated girls with TS, a randomized, placebo-controlled, double-blind study was conducted. 133 patients were treated with GH (1.33 mg/m(2)/d) from baseline, combined with placebo (Pl), Ox 0.03 mg/kg/d, or Ox 0.06 mg/kg/d from the age of eight, and with estrogens from the age of 12. The child behavior checklist (CBCL), Junior Dutch Personality Questionnaire (DPQ-J), State-subscale of the Spielberger's State-Trait Anger Scale, Romantic and Sexual Interest Questionnaire, Mood Questionnaire, and Gender Role Questionnaire were filled out before, during, and after discontinuing Ox/Pl. The changes during Ox/Pl therapy were not significantly different between the dosage groups. In untreated patients, the mean CBCL total (P=0.002) and internalizing (P=0.003) T scores, as well as the mean DPQ-J social inadequacy SD score (SDS) (P=0.004) were higher than in reference girls, but decreased during GH+Ox/Pl therapy (P<0.001, P=0.05, P<0.001, respectively). Whereas the mean total (P=0.01) and internalizing (P<0.001) T score remained relatively high, the mean social inadequacy SDS became comparable with reference values. We conclude that in GH-treated girls with TS, Ox 0.03 mg/kg/d or 0.06 mg/kg/d does not cause evident psychological virilizing side effects. Problem behavior, frequently present in untreated girls with TS, decreases during therapy, but total and internalizing problem behavior remain increased.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
1095-6867
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| pubmed:author |
pubmed-author:Cohen-KettenisPeggy TPT,
pubmed-author:KreukelsBaudewijntje P CBP,
pubmed-author:MenkeLeonie ALA,
pubmed-author:OttenBarto JBJ,
pubmed-author:SasTheo C JTC,
pubmed-author:StijnenTheoT,
pubmed-author:VisserMartjeM,
pubmed-author:WitJan MJM,
pubmed-author:ZandwijkenGladys R JGR,
pubmed-author:de Muinck Keizer-SchramaSabine M P FSM
|
| pubmed:copyrightInfo |
Copyright 2009 Elsevier Inc. All rights reserved.
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| pubmed:issnType |
Electronic
|
| pubmed:volume |
57
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
297-305
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| pubmed:meshHeading |
pubmed-meshheading:20053349-Adolescent,
pubmed-meshheading:20053349-Affect,
pubmed-meshheading:20053349-Aggression,
pubmed-meshheading:20053349-Androgens,
pubmed-meshheading:20053349-Child,
pubmed-meshheading:20053349-Child, Preschool,
pubmed-meshheading:20053349-Double-Blind Method,
pubmed-meshheading:20053349-Drug Therapy, Combination,
pubmed-meshheading:20053349-Emotions,
pubmed-meshheading:20053349-Estrogens,
pubmed-meshheading:20053349-Female,
pubmed-meshheading:20053349-Gender Identity,
pubmed-meshheading:20053349-Human Growth Hormone,
pubmed-meshheading:20053349-Humans,
pubmed-meshheading:20053349-Mental Disorders,
pubmed-meshheading:20053349-Oxandrolone,
pubmed-meshheading:20053349-Sexuality,
pubmed-meshheading:20053349-Treatment Outcome,
pubmed-meshheading:20053349-Turner Syndrome
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
The effect of the weak androgen oxandrolone on psychological and behavioral characteristics in growth hormone-treated girls with Turner syndrome.
|
| pubmed:affiliation |
Leiden University Medical Center, Department of Pediatrics, Leiden, the Netherlands. l.a.menke@lumc.nl
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| pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|