|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2010-2-9
|
|
pubmed:abstractText |
In order to investigate the molecular features involved in sigma receptors (sigma-Rs) binding, new compounds based on arylalkylaminoalcoholic, arylalkenyl- and arylalkylaminic scaffolds were synthesized and their affinity towards sigma(1)- and sigma(2)-Rs subtypes was evaluated. The most promising compounds were also screened for their affinity at micro-opioid, delta-opioid and kappa-opioid receptors. Biological results are herein presented and discussed.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
1464-3391
|
|
pubmed:author |
pubmed-author:AzzolinaOrnellaO,
pubmed-author:CollinaSimonaS,
pubmed-author:FlorioChiaraC,
pubmed-author:LaggnerChristianC,
pubmed-author:MamoloMaria GraziaMG,
pubmed-author:PedraliAliceA,
pubmed-author:RossiDanielaD,
pubmed-author:SchepmannDirkD,
pubmed-author:SerraMassimoM,
pubmed-author:UrbanoMariangelaM,
pubmed-author:WuenschBernardB,
pubmed-author:ZampieriDanieleD,
pubmed-author:ZanetteCaterinaC
|
|
pubmed:copyrightInfo |
Copyright (c) 2009 Elsevier Ltd. All rights reserved.
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
18
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1204-12
|
|
pubmed:meshHeading |
pubmed-meshheading:20045339-Alkenes,
pubmed-meshheading:20045339-Amines,
pubmed-meshheading:20045339-Amino Alcohols,
pubmed-meshheading:20045339-Animals,
pubmed-meshheading:20045339-Guinea Pigs,
pubmed-meshheading:20045339-Hydrocarbons, Aromatic,
pubmed-meshheading:20045339-Ligands,
pubmed-meshheading:20045339-Models, Molecular,
pubmed-meshheading:20045339-Protein Binding,
pubmed-meshheading:20045339-Rats,
pubmed-meshheading:20045339-Receptors, Opioid,
pubmed-meshheading:20045339-Receptors, sigma,
pubmed-meshheading:20045339-Structure-Activity Relationship
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Design, synthesis and SAR analysis of novel selective sigma1 ligands (Part 2).
|
|
pubmed:affiliation |
Department of Pharmaceutical Chemistry, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
