Linked Life Data

20033834

Source:http://linkedlifedata.com/resource/pubmed/id/20033834

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2010-3-11
pubmed:abstractText
Autologous nerve grafts are widely used in bridging critical gaps of peripheral nerves, but they remain associated with high morbidity of the donor site and lack of full recovery. As an alternative, we have focused on chitosan nerve conduits filled with a heparin-incorporated fibrin-fibronectin matrix serving as delivery systems for basic fibroblast growth factor (bFGF). The artificial nerve conduits were used for repairing sciatic nerve defects of 10 mm in adult rats. Three months post-operation, the conduction velocity recovery index (CVRI) and the muscle restoration rate (MRR) in animals of the experimental group were 32 +/- 4.1 and 77.4 +/- 7.9%, respectively, which were significantly higher than those of the PBS control group (17.8 +/- 1.9 and 66.7 +/- 6.5%), and similar to those of the autograft group (38.4 +/- 3.9 and 81.3 +/- 7.8%). These results were also consistent with the densities of regenerated axons in the three groups, which were demonstrated by histomorphological analysis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1573-6776
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
585-91
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
A novel basic fibroblast growth factor delivery system fabricated with heparin-incorporated fibrin-fibronectin matrices for repairing rat sciatic nerve disruptions.
pubmed:affiliation
Institute of Neurological Disorders, Yuquan Hospital, Tsinghua University, Beijing 100049, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't