Linked Life Data

20032478

Source:http://linkedlifedata.com/resource/pubmed/id/20032478

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2010-1-21
pubmed:abstractText
Our objective was to examine the effect of a quercetin supplementation on blood pressure, lipid metabolism, markers of oxidative stress, inflammation, and body composition in an at-risk population of 93 overweight-obese volunteers aged 25-65 y with metabolic syndrome traits in relation to apolipoprotein (apo) E genotype. Participants were randomized to receive 150 mg/d quercetin in a double-blinded, placebo-controlled, crossover trial with 6-wk treatment periods separated by a 5-wk washout period. Retrospectively, 5 apoE genotype variants were found (epsilon2/epsilon3, n = 3; epsilon3/epsilon3, n = 60; epsilon3/epsilon4, n = 23; epsilon2/epsilon4, n = 4; and epsilon4/epsilon4, n = 3). Participants were classified into the following 3 apoE phenotypes: apoE2 (n = 3), apoE3 (n = 60), and apoE4 (n = 26). Data were analyzed for apoE3 and apoE4 subgroups. Quercetin decreased systolic blood pressure by 3.4 mm Hg (P < 0.01) in the apoE3 group, whereas no significant effect was observed in the apoE4 group. Quercetin decreased serum HDL cholesterol (P < 0.01) and apoA1 (P < 0.01) and increased the LDL:HDL cholesterol ratio (P < 0.05) in the apoE4 subgroup, whereas the apoE3 subgroup had no significant changes in these variables. Quercetin significantly decreased plasma oxidized LDL and tumor necrosis factor-alpha in the apoE3 and apoE4 groups, whereas no significant inter-group differences were found. Serum C-reactive protein and nutritional status (body weight, waist circumference, fat mass, fat-free mass) were unaffected compared with placebo. In conclusion, quercetin exhibited blood pressure-lowering effects in overweight-obese carriers of the apo epsilon3/epsilon3 genotype but not in carriers of the epsilon4 allele. Furthermore, quercetin supplementation resulted in a reduction in HDL cholesterol and apoA1 in apo epsilon4 carriers.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1541-6100
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
140
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
278-84
pubmed:meshHeading
pubmed-meshheading:20032478-Adult, pubmed-meshheading:20032478-Antioxidants, pubmed-meshheading:20032478-Apolipoproteins E, pubmed-meshheading:20032478-Blood Pressure, pubmed-meshheading:20032478-Cholesterol, HDL, pubmed-meshheading:20032478-Cholesterol, LDL, pubmed-meshheading:20032478-Cross-Over Studies, pubmed-meshheading:20032478-Double-Blind Method, pubmed-meshheading:20032478-Female, pubmed-meshheading:20032478-Humans, pubmed-meshheading:20032478-Male, pubmed-meshheading:20032478-Middle Aged, pubmed-meshheading:20032478-Obesity, pubmed-meshheading:20032478-Phenotype, pubmed-meshheading:20032478-Phytotherapy, pubmed-meshheading:20032478-Plant Extracts, pubmed-meshheading:20032478-Polymorphism, Single Nucleotide, pubmed-meshheading:20032478-Quercetin, pubmed-meshheading:20032478-Tumor Necrosis Factor-alpha
pubmed:year
2010
pubmed:articleTitle
Serum lipid and blood pressure responses to quercetin vary in overweight patients by apolipoprotein E genotype.
pubmed:affiliation
Institute of Nutrition and Food Science, Nutritional Physiology, University of Bonn, 53115 Bonn, Germany.
pubmed:publicationType
Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't