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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2009-12-24
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pubmed:abstractText |
FTO is the first gene established as contributing to common forms of obesity. The gene is highly expressed in the hypothalamus and is thought to mediate this effect through its influence on energy homeostasis. The hypothalamus, however, also regulates blood pressure (BP). Therefore, we investigated whether the FTO-risk variant is associated not only with increased adiposity but also with elevated BP and whether the latter may be mediated, in part, by increased sympathetic modulation of vasomotor tone.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1942-3268
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pubmed:author |
pubmed-author:AbrahamowiczMichalM,
pubmed-author:GaudetDanielD,
pubmed-author:HametPavelP,
pubmed-author:LeonardGabriel TGT,
pubmed-author:PausTomasT,
pubmed-author:PausovaZdenkaZ,
pubmed-author:PerronMichelM,
pubmed-author:RicherLouisL,
pubmed-author:SedaOndrejO,
pubmed-author:SmithGeorge DaveyGD,
pubmed-author:SymeCatrionaC,
pubmed-author:TremblayJohanneJ,
pubmed-author:VeilletteSuzanneS,
pubmed-author:XiaoYonglingY
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pubmed:issnType |
Electronic
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
260-9
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pubmed:meshHeading |
pubmed-meshheading:20031594-Adipose Tissue,
pubmed-meshheading:20031594-Adiposity,
pubmed-meshheading:20031594-Adolescent,
pubmed-meshheading:20031594-Adult,
pubmed-meshheading:20031594-Aged,
pubmed-meshheading:20031594-Blood Pressure,
pubmed-meshheading:20031594-Canada,
pubmed-meshheading:20031594-Child,
pubmed-meshheading:20031594-European Continental Ancestry Group,
pubmed-meshheading:20031594-Female,
pubmed-meshheading:20031594-Founder Effect,
pubmed-meshheading:20031594-France,
pubmed-meshheading:20031594-Genetic Predisposition to Disease,
pubmed-meshheading:20031594-Genome-Wide Association Study,
pubmed-meshheading:20031594-Genotype,
pubmed-meshheading:20031594-Glucose,
pubmed-meshheading:20031594-Humans,
pubmed-meshheading:20031594-Hypertension,
pubmed-meshheading:20031594-Male,
pubmed-meshheading:20031594-Middle Aged,
pubmed-meshheading:20031594-Obesity,
pubmed-meshheading:20031594-Phenotype,
pubmed-meshheading:20031594-Proteins,
pubmed-meshheading:20031594-Vasomotor System
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pubmed:year |
2009
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pubmed:articleTitle |
A common variant of the FTO gene is associated with not only increased adiposity but also elevated blood pressure in French Canadians.
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pubmed:affiliation |
Brain and Body Centre, University of Nottingham, Nottingham, United Kingdom. zdenka.pausova@nottingham.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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