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rdf:type |
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lifeskim:mentions |
umls-concept:C0026882,
umls-concept:C0150312,
umls-concept:C0205195,
umls-concept:C0205210,
umls-concept:C0205419,
umls-concept:C0332325,
umls-concept:C0370215,
umls-concept:C0445750,
umls-concept:C0449943,
umls-concept:C1260298,
umls-concept:C1515333
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|
pubmed:issue |
3
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|
pubmed:dateCreated |
2010-2-22
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|
pubmed:abstractText |
A Salmonella enterica serovar Hadar strain resistant to tigecycline (MIC, 16 microg/ml) was isolated. Molecular characterization revealed the presence of a plasmid-borne tet(A) variant associated with Tn1721 mediating a rise of the MIC for tigecycline when transferred to Escherichia coli. Additionally, a truncating mutation in ramR was detected. Transformation with wild-type ramR but not with the mutated ramR lowered the MIC for tigecycline. Characterization of this Salmonella isolate implicates ramR in resistance to tigecycline.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
1098-6596
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|
pubmed:author |
|
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pubmed:issnType |
Electronic
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1319-22
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pubmed:dateRevised |
2010-9-2
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pubmed:meshHeading |
pubmed-meshheading:20028818-Anti-Bacterial Agents,
pubmed-meshheading:20028818-Antiporters,
pubmed-meshheading:20028818-Bacterial Proteins,
pubmed-meshheading:20028818-DNA Transposable Elements,
pubmed-meshheading:20028818-Drug Resistance, Bacterial,
pubmed-meshheading:20028818-Genetic Variation,
pubmed-meshheading:20028818-Humans,
pubmed-meshheading:20028818-Minocycline,
pubmed-meshheading:20028818-Mutation,
pubmed-meshheading:20028818-Repressor Proteins,
pubmed-meshheading:20028818-Salmonella enterica
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|
pubmed:year |
2010
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|
pubmed:articleTitle |
Combined ramR mutation and presence of a Tn1721-associated tet(A) variant in a clinical isolate of Salmonella enterica serovar Hadar resistant to tigecycline.
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|
pubmed:affiliation |
Institut für Medizinische Mikrobiologie, Virologie und Hygiene, Universitätsklinikum Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany. m.hentschke@uke.de
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pubmed:publicationType |
Journal Article
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