Linked Life Data

20028765

Source:http://linkedlifedata.com/resource/pubmed/id/20028765

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-1-5
pubmed:abstractText
The mammalian target of rapamycin (mTOR) inhibitor temsirolimus has exhibited promising anticancer activity for the treatment of renal cell cancers (RCC). Survivin expression has been implicated in drug resistance and reducing its levels with the histone deacetylase (HDAC) inhibitor vorinostat may enhance the anticancer activity of temsirolimus.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1078-0432
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
141-53
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:20028765-Angiogenesis Inhibitors, pubmed-meshheading:20028765-Animals, pubmed-meshheading:20028765-Antineoplastic Combined Chemotherapy Protocols, pubmed-meshheading:20028765-Apoptosis, pubmed-meshheading:20028765-Carcinoma, Renal Cell, pubmed-meshheading:20028765-Cell Line, Tumor, pubmed-meshheading:20028765-Drug Synergism, pubmed-meshheading:20028765-Humans, pubmed-meshheading:20028765-Hydroxamic Acids, pubmed-meshheading:20028765-Inhibitor of Apoptosis Proteins, pubmed-meshheading:20028765-Kidney Neoplasms, pubmed-meshheading:20028765-Mice, pubmed-meshheading:20028765-Mice, Nude, pubmed-meshheading:20028765-Microtubule-Associated Proteins, pubmed-meshheading:20028765-Repressor Proteins, pubmed-meshheading:20028765-Sirolimus, pubmed-meshheading:20028765-Xenograft Model Antitumor Assays
pubmed:year
2010
pubmed:articleTitle
Vorinostat enhances the activity of temsirolimus in renal cell carcinoma through suppression of survivin levels.
pubmed:affiliation
Institute for Drug Development, Cancer Therapy and Research Center at The University of Texas Health Science Center, San Antonio, Texas 78245, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural