| pubmed-article:20026056 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20026056 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:20026056 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:20026056 | lifeskim:mentions | umls-concept:C0039198 | lld:lifeskim |
| pubmed-article:20026056 | lifeskim:mentions | umls-concept:C1415900 | lld:lifeskim |
| pubmed-article:20026056 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:20026056 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:20026056 | pubmed:dateCreated | 2010-1-27 | lld:pubmed |
| pubmed-article:20026056 | pubmed:abstractText | Foxp3(+)CD4(+) regulatory T cells (Treg) control not only autoimmunity but also the effective immune response against RNA virus infections, which produces virus-derived double-stranded RNA (dsRNA). To induce effective anti-viral immunity, it is a key issue to learn how Treg respond to dsRNA in vitro and in vivo. We here showed that synthetic dsRNA, polyI:C, caused peripheral expansion of functional Treg in a TICAM-1- and IL-6-dependent manner in vivo. PolyI:C did not expand Treg directly, but promoted the expansion of naturally occurring Treg indirectly through IL-6 produced from dendritic cells (DCs). In addition, the expansion of Treg by IL-6 was inhibited by IFN-alpha from polyI:C-stimulated DCs. These data suggest that the balance of IL-6 and IFN-alpha in the region of RNA virus infection may determine the number of peripheral Treg, which affects the effective immune responses against viruses. | lld:pubmed |
| pubmed-article:20026056 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20026056 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20026056 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20026056 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20026056 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20026056 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20026056 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20026056 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20026056 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20026056 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20026056 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20026056 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:20026056 | pubmed:issn | 1090-2104 | lld:pubmed |
| pubmed-article:20026056 | pubmed:author | pubmed-author:MatsumotoMisa... | lld:pubmed |
| pubmed-article:20026056 | pubmed:author | pubmed-author:SeyaTsukasaT | lld:pubmed |
| pubmed-article:20026056 | pubmed:author | pubmed-author:GandoSatoshiS | lld:pubmed |
| pubmed-article:20026056 | pubmed:author | pubmed-author:EbiharaTakash... | lld:pubmed |
| pubmed-article:20026056 | pubmed:author | pubmed-author:KubotaNobuhik... | lld:pubmed |
| pubmed-article:20026056 | pubmed:copyrightInfo | Copyright 2009 Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:20026056 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20026056 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:20026056 | pubmed:volume | 391 | lld:pubmed |
| pubmed-article:20026056 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20026056 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20026056 | pubmed:pagination | 1421-6 | lld:pubmed |
| pubmed-article:20026056 | pubmed:meshHeading | pubmed-meshheading:20026056... | lld:pubmed |
| pubmed-article:20026056 | pubmed:meshHeading | pubmed-meshheading:20026056... | lld:pubmed |
| pubmed-article:20026056 | pubmed:meshHeading | pubmed-meshheading:20026056... | lld:pubmed |
| pubmed-article:20026056 | pubmed:meshHeading | pubmed-meshheading:20026056... | lld:pubmed |
| pubmed-article:20026056 | pubmed:meshHeading | pubmed-meshheading:20026056... | lld:pubmed |
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| pubmed-article:20026056 | pubmed:meshHeading | pubmed-meshheading:20026056... | lld:pubmed |
| pubmed-article:20026056 | pubmed:meshHeading | pubmed-meshheading:20026056... | lld:pubmed |
| pubmed-article:20026056 | pubmed:meshHeading | pubmed-meshheading:20026056... | lld:pubmed |
| pubmed-article:20026056 | pubmed:meshHeading | pubmed-meshheading:20026056... | lld:pubmed |
| pubmed-article:20026056 | pubmed:meshHeading | pubmed-meshheading:20026056... | lld:pubmed |
| pubmed-article:20026056 | pubmed:meshHeading | pubmed-meshheading:20026056... | lld:pubmed |
| pubmed-article:20026056 | pubmed:meshHeading | pubmed-meshheading:20026056... | lld:pubmed |
| pubmed-article:20026056 | pubmed:meshHeading | pubmed-meshheading:20026056... | lld:pubmed |
| pubmed-article:20026056 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20026056 | pubmed:articleTitle | IL-6 and IFN-alpha from dsRNA-stimulated dendritic cells control expansion of regulatory T cells. | lld:pubmed |
| pubmed-article:20026056 | pubmed:affiliation | Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan. | lld:pubmed |
| pubmed-article:20026056 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20026056 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:106759 | entrezgene:pubmed | pubmed-article:20026056 | lld:entrezgene |
