rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2010-1-27
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pubmed:abstractText |
Foxp3(+)CD4(+) regulatory T cells (Treg) control not only autoimmunity but also the effective immune response against RNA virus infections, which produces virus-derived double-stranded RNA (dsRNA). To induce effective anti-viral immunity, it is a key issue to learn how Treg respond to dsRNA in vitro and in vivo. We here showed that synthetic dsRNA, polyI:C, caused peripheral expansion of functional Treg in a TICAM-1- and IL-6-dependent manner in vivo. PolyI:C did not expand Treg directly, but promoted the expansion of naturally occurring Treg indirectly through IL-6 produced from dendritic cells (DCs). In addition, the expansion of Treg by IL-6 was inhibited by IFN-alpha from polyI:C-stimulated DCs. These data suggest that the balance of IL-6 and IFN-alpha in the region of RNA virus infection may determine the number of peripheral Treg, which affects the effective immune responses against viruses.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Vesicular...,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Poly C,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Double-Stranded,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/TICAM-1 protein, mouse
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1090-2104
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2009 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
391
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1421-6
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pubmed:meshHeading |
pubmed-meshheading:20026056-Adaptor Proteins, Vesicular Transport,
pubmed-meshheading:20026056-Animals,
pubmed-meshheading:20026056-Bone Marrow Cells,
pubmed-meshheading:20026056-Cell Proliferation,
pubmed-meshheading:20026056-Cells, Cultured,
pubmed-meshheading:20026056-Dendritic Cells,
pubmed-meshheading:20026056-Interferon-alpha,
pubmed-meshheading:20026056-Interleukin-6,
pubmed-meshheading:20026056-Lymphocyte Activation,
pubmed-meshheading:20026056-Mice,
pubmed-meshheading:20026056-Mice, Mutant Strains,
pubmed-meshheading:20026056-Poly C,
pubmed-meshheading:20026056-RNA, Double-Stranded,
pubmed-meshheading:20026056-RNA, Viral,
pubmed-meshheading:20026056-Rats,
pubmed-meshheading:20026056-T-Lymphocytes, Regulatory
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pubmed:year |
2010
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pubmed:articleTitle |
IL-6 and IFN-alpha from dsRNA-stimulated dendritic cells control expansion of regulatory T cells.
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pubmed:affiliation |
Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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