Source:http://linkedlifedata.com/resource/pubmed/id/20015648
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2010-2-3
|
| pubmed:abstractText |
A novel hexahydrobenzonaphthyridinone PARP-1 pharmacophore is reported, subsequent SAR exploration around this scaffold led to selective PARP-1 inhibitors with low nanomolar enzyme potency, displaying good cellular activity and promising rat PK properties.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
1464-3405
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 2009 Elsevier Ltd. All rights reserved.
|
| pubmed:issnType |
Electronic
|
| pubmed:day |
15
|
| pubmed:volume |
20
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
448-52
|
| pubmed:meshHeading |
pubmed-meshheading:20015648-Animals,
pubmed-meshheading:20015648-Drug Discovery,
pubmed-meshheading:20015648-Enzyme Inhibitors,
pubmed-meshheading:20015648-Microsomes, Liver,
pubmed-meshheading:20015648-Naphthyridines,
pubmed-meshheading:20015648-Poly(ADP-ribose) Polymerases,
pubmed-meshheading:20015648-Rats,
pubmed-meshheading:20015648-Structure-Activity Relationship
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
Discovery and SAR of novel, potent and selective hexahydrobenzonaphthyridinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1).
|
| pubmed:affiliation |
IRBM-Merck Research Laboratories Rome, Via Pontina km 30,600, Pomezia, 00040 Rome, Italy. caterina.torrisi@addexpharma.com
|
| pubmed:publicationType |
Journal Article
|