Overview of the Disease ProcessIncidencePrognostic or Predictive FactorsCurrent General Therapy StandardsSurgeryCombined Treatment ModalitiesAccomplishments in 2008TherapyBiomarkers & Basic ScienceWhat Needs to be DoneApplications of the AccomplishmentsControversies and DisagreementsSpecial PopulationsFuture DirectionsComments on ResearchObstacles to Progress.