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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2009-12-22
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pubmed:abstractText |
Disturbances in central serotonin function have been implicated in impulsive and aggressive behavior. A deletion/insertion polymorphism within the 5-HT transporter promoter gene (5-HTTLPR) is thought to be associated with disturbed impulse control, anxiety, and depression. The serotonin transporter (5-HTT) is the primary action site for selective serotonin reuptake inhibitors (SSRIs). Several studies of major depression have shown that the l allele of 5-HTTLPR is associated with better SSRI antidepressant effects than the s allele.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1473-5873
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
25-30
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pubmed:meshHeading |
pubmed-meshheading:20010449-Adolescent,
pubmed-meshheading:20010449-Adult,
pubmed-meshheading:20010449-Aged,
pubmed-meshheading:20010449-Aggression,
pubmed-meshheading:20010449-Alleles,
pubmed-meshheading:20010449-Female,
pubmed-meshheading:20010449-Fluoxetine,
pubmed-meshheading:20010449-Genotype,
pubmed-meshheading:20010449-Humans,
pubmed-meshheading:20010449-Impulsive Behavior,
pubmed-meshheading:20010449-Male,
pubmed-meshheading:20010449-Middle Aged,
pubmed-meshheading:20010449-Personality Disorders,
pubmed-meshheading:20010449-Polymorphism, Genetic,
pubmed-meshheading:20010449-Psychiatric Status Rating Scales,
pubmed-meshheading:20010449-Serotonin Plasma Membrane Transport Proteins,
pubmed-meshheading:20010449-Serotonin Uptake Inhibitors,
pubmed-meshheading:20010449-Young Adult
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pubmed:year |
2010
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pubmed:articleTitle |
Fluoxetine response in impulsive-aggressive behavior and serotonin transporter polymorphism in personality disorder.
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pubmed:affiliation |
Psychiatric Clinic of University of Chile, Santiago de Chile, Chile. hsilva@med.uchile.cl
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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