Linked Life Data

20006713

Source:http://linkedlifedata.com/resource/pubmed/id/20006713

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-2-9
pubmed:abstractText
Mild cognitive impairment (MCI) is the transitional, heterogeneous continuum from healthy elderly to Alzheimer's disease (AD). Previous studies have shown that brain functional activity in the default mode network (DMN) is impaired in AD patients. However, altering DMN activity patterns in MCI patients remains largely unclear. The present study utilized resting-state functional magnetic resonance imaging (fMRI) and an independent component analysis (ICA) approach to investigate DMN activity in 14 amnestic MCI (aMCI) patients and 14 healthy elderly. Compared to the aMCI patients, the healthy elderly exhibited increased functional activity in the DMN regions, including the bilateral precuneus/posterior cingulate cortex, right inferior parietal lobule, and left fusiform gyrus, as well as a trend towards increased right medial temporal lobe activity. The aMCI patients exhibited increased activity in the left prefrontal cortex, inferior parietal lobule, and middle temporal gyrus compared to the healthy elderly. Increased frontal-parietal activity may indicate compensatory processes in the aMCI patients. These findings suggest that abnormal DMN activity could be useful as an imaging-based biomarker for the diagnosis and monitoring of aMCI patients.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1095-9572
pubmed:author
pubmed:copyrightInfo
Copyright (c) 2009 Elsevier Inc. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
48-55
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Impairment and compensation coexist in amnestic MCI default mode network.
pubmed:affiliation
Department of Radiology, Xuanwu Hospital of Capital University of Medical Sciences, Beijing 100053, PR China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't