| pubmed-article:20006609 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20006609 | lifeskim:mentions | umls-concept:C0178539 | lld:lifeskim |
| pubmed-article:20006609 | lifeskim:mentions | umls-concept:C0012860 | lld:lifeskim |
| pubmed-article:20006609 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:20006609 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:20006609 | lifeskim:mentions | umls-concept:C1424440 | lld:lifeskim |
| pubmed-article:20006609 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:20006609 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:20006609 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:20006609 | pubmed:dateCreated | 2010-1-27 | lld:pubmed |
| pubmed-article:20006609 | pubmed:abstractText | DNA damage checkpoints are essential for maintenance of genome integrity. We report here that inducible overexpression of the transcription factor Sharp-1 results in an S and G2/M cell cycle arrest, concomitant with the upregulation of Brca1 and GADD45alpha expression. In addition, we show that endogenous Sharp-1 mRNA is increased by DNA-damaging agents. Consistently, Sharp-1 overexpressing cells exhibit reduced apoptosis in response to chemotherapeutic drugs along with lower p53 expression and activity. Our studies identify a novel function for Sharp-1 in cell cycle arrest and DNA damage-induced apoptosis. Inappropriate Sharp-1 expression may therefore be associated with tumorigenesis. | lld:pubmed |
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| pubmed-article:20006609 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20006609 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20006609 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:20006609 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20006609 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:20006609 | pubmed:issn | 1873-3468 | lld:pubmed |
| pubmed-article:20006609 | pubmed:author | pubmed-author:LiuJian-JunJJ | lld:pubmed |
| pubmed-article:20006609 | pubmed:author | pubmed-author:LiJialiJ | lld:pubmed |
| pubmed-article:20006609 | pubmed:author | pubmed-author:TanejaReshmaR | lld:pubmed |
| pubmed-article:20006609 | pubmed:author | pubmed-author:ChungTeng-Kai... | lld:pubmed |
| pubmed-article:20006609 | pubmed:copyrightInfo | 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. | lld:pubmed |
| pubmed-article:20006609 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20006609 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:20006609 | pubmed:volume | 584 | lld:pubmed |
| pubmed-article:20006609 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20006609 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20006609 | pubmed:pagination | 619-24 | lld:pubmed |
| pubmed-article:20006609 | pubmed:dateRevised | 2011-7-25 | lld:pubmed |
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| pubmed-article:20006609 | pubmed:meshHeading | pubmed-meshheading:20006609... | lld:pubmed |
| pubmed-article:20006609 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20006609 | pubmed:articleTitle | Sharp-1 modulates the cellular response to DNA damage. | lld:pubmed |
| pubmed-article:20006609 | pubmed:affiliation | Department of Physiology, National University of Singapore, Singapore, Singapore. | lld:pubmed |
| pubmed-article:20006609 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20006609 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20006609 | lld:entrezgene |
