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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2010-1-27
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pubmed:abstractText |
DNA damage checkpoints are essential for maintenance of genome integrity. We report here that inducible overexpression of the transcription factor Sharp-1 results in an S and G2/M cell cycle arrest, concomitant with the upregulation of Brca1 and GADD45alpha expression. In addition, we show that endogenous Sharp-1 mRNA is increased by DNA-damaging agents. Consistently, Sharp-1 overexpressing cells exhibit reduced apoptosis in response to chemotherapeutic drugs along with lower p53 expression and activity. Our studies identify a novel function for Sharp-1 in cell cycle arrest and DNA damage-induced apoptosis. Inappropriate Sharp-1 expression may therefore be associated with tumorigenesis.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20006609-10572178,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20006609-10737769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20006609-10856933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20006609-11100718,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20006609-11313928,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20006609-12657651,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20006609-12917355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20006609-14500851,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20006609-15108799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20006609-15448136,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20006609-16103751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20006609-17303408,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20006609-17347673,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20006609-17659913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20006609-19029947,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20006609-19730431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20006609-9122197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20006609-9552387
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/BRCA1 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Bhlhb3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cisplatin,
http://linkedlifedata.com/resource/pubmed/chemical/Etoposide,
http://linkedlifedata.com/resource/pubmed/chemical/Fluorouracil,
http://linkedlifedata.com/resource/pubmed/chemical/Gadd45a protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1873-3468
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pubmed:author |
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pubmed:copyrightInfo |
2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
5
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pubmed:volume |
584
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
619-24
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pubmed:dateRevised |
2011-7-25
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pubmed:meshHeading |
pubmed-meshheading:20006609-Animals,
pubmed-meshheading:20006609-BRCA1 Protein,
pubmed-meshheading:20006609-Blotting, Western,
pubmed-meshheading:20006609-Caspase 3,
pubmed-meshheading:20006609-Cell Cycle,
pubmed-meshheading:20006609-Cell Cycle Proteins,
pubmed-meshheading:20006609-Cisplatin,
pubmed-meshheading:20006609-DNA Damage,
pubmed-meshheading:20006609-Etoposide,
pubmed-meshheading:20006609-Fluorouracil,
pubmed-meshheading:20006609-Mice,
pubmed-meshheading:20006609-NIH 3T3 Cells,
pubmed-meshheading:20006609-Nuclear Proteins,
pubmed-meshheading:20006609-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:20006609-Transcription Factors,
pubmed-meshheading:20006609-Tumor Suppressor Protein p53
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pubmed:year |
2010
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pubmed:articleTitle |
Sharp-1 modulates the cellular response to DNA damage.
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pubmed:affiliation |
Department of Physiology, National University of Singapore, Singapore, Singapore.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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