| pubmed-article:20005870 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20005870 | lifeskim:mentions | umls-concept:C0242290 | lld:lifeskim |
| pubmed-article:20005870 | lifeskim:mentions | umls-concept:C0596290 | lld:lifeskim |
| pubmed-article:20005870 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:20005870 | lifeskim:mentions | umls-concept:C1839613 | lld:lifeskim |
| pubmed-article:20005870 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:20005870 | lifeskim:mentions | umls-concept:C1883221 | lld:lifeskim |
| pubmed-article:20005870 | lifeskim:mentions | umls-concept:C0162610 | lld:lifeskim |
| pubmed-article:20005870 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:20005870 | lifeskim:mentions | umls-concept:C0004916 | lld:lifeskim |
| pubmed-article:20005870 | lifeskim:mentions | umls-concept:C1883204 | lld:lifeskim |
| pubmed-article:20005870 | lifeskim:mentions | umls-concept:C1880389 | lld:lifeskim |
| pubmed-article:20005870 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:20005870 | pubmed:dateCreated | 2010-2-1 | lld:pubmed |
| pubmed-article:20005870 | pubmed:abstractText | The control of cell division is critical to organogenesis, but how this control is achieved is not fully understood. We found that mutations in bed-3, encoding a BED Zn-finger domain transcription factor, confer a phenotype where a specific set of cell divisions during vulval organogenesis is lost. Unlike general cell cycle regulators in Caenorhabditis elegans, the function of bed-3 is restricted to specific lineages. Transcriptional reporters suggest that bed-3 is expressed in a limited number of cell types including vulval cells whose divisions are affected in bed-3 mutants. A bed-3 mutation also affects the expression pattern of the cdh-3 cadherin gene in the vulva. The phenotype of bed-3 mutants is similar to the phenotype caused by mutations in cog-1 (Nkx6), a component of a gene regulatory network controlling cell type specific gene expression in the vulval lineage. These results suggest that bed-3 is a key component linking the gene regulatory network controlling cell-type specification to control of cell division during vulval organogenesis. | lld:pubmed |
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| pubmed-article:20005870 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20005870 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20005870 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20005870 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20005870 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20005870 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20005870 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:20005870 | pubmed:issn | 1095-564X | lld:pubmed |
| pubmed-article:20005870 | pubmed:author | pubmed-author:SternbergPaul... | lld:pubmed |
| pubmed-article:20005870 | pubmed:author | pubmed-author:InoueTakaoT | lld:pubmed |
| pubmed-article:20005870 | pubmed:copyrightInfo | Copyright 2009 Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:20005870 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20005870 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:20005870 | pubmed:volume | 338 | lld:pubmed |
| pubmed-article:20005870 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20005870 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20005870 | pubmed:pagination | 226-36 | lld:pubmed |
| pubmed-article:20005870 | pubmed:dateRevised | 2010-9-27 | lld:pubmed |
| pubmed-article:20005870 | pubmed:meshHeading | pubmed-meshheading:20005870... | lld:pubmed |
| pubmed-article:20005870 | pubmed:meshHeading | pubmed-meshheading:20005870... | lld:pubmed |
| pubmed-article:20005870 | pubmed:meshHeading | pubmed-meshheading:20005870... | lld:pubmed |
| pubmed-article:20005870 | pubmed:meshHeading | pubmed-meshheading:20005870... | lld:pubmed |
| pubmed-article:20005870 | pubmed:meshHeading | pubmed-meshheading:20005870... | lld:pubmed |
| pubmed-article:20005870 | pubmed:meshHeading | pubmed-meshheading:20005870... | lld:pubmed |
| pubmed-article:20005870 | pubmed:meshHeading | pubmed-meshheading:20005870... | lld:pubmed |
| pubmed-article:20005870 | pubmed:meshHeading | pubmed-meshheading:20005870... | lld:pubmed |
| pubmed-article:20005870 | pubmed:meshHeading | pubmed-meshheading:20005870... | lld:pubmed |
| pubmed-article:20005870 | pubmed:meshHeading | pubmed-meshheading:20005870... | lld:pubmed |
| pubmed-article:20005870 | pubmed:meshHeading | pubmed-meshheading:20005870... | lld:pubmed |
| pubmed-article:20005870 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20005870 | pubmed:articleTitle | C. elegans BED domain transcription factor BED-3 controls lineage-specific cell proliferation during organogenesis. | lld:pubmed |
| pubmed-article:20005870 | pubmed:affiliation | Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. bchti@nus.edu.sg | lld:pubmed |
| pubmed-article:20005870 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20005870 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
