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rdf:type |
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lifeskim:mentions |
umls-concept:C0004916,
umls-concept:C0040648,
umls-concept:C0162610,
umls-concept:C0242290,
umls-concept:C0596290,
umls-concept:C1514562,
umls-concept:C1839613,
umls-concept:C1880389,
umls-concept:C1883204,
umls-concept:C1883221,
umls-concept:C2587213
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pubmed:issue |
2
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pubmed:dateCreated |
2010-2-1
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pubmed:abstractText |
The control of cell division is critical to organogenesis, but how this control is achieved is not fully understood. We found that mutations in bed-3, encoding a BED Zn-finger domain transcription factor, confer a phenotype where a specific set of cell divisions during vulval organogenesis is lost. Unlike general cell cycle regulators in Caenorhabditis elegans, the function of bed-3 is restricted to specific lineages. Transcriptional reporters suggest that bed-3 is expressed in a limited number of cell types including vulval cells whose divisions are affected in bed-3 mutants. A bed-3 mutation also affects the expression pattern of the cdh-3 cadherin gene in the vulva. The phenotype of bed-3 mutants is similar to the phenotype caused by mutations in cog-1 (Nkx6), a component of a gene regulatory network controlling cell type specific gene expression in the vulval lineage. These results suggest that bed-3 is a key component linking the gene regulatory network controlling cell-type specification to control of cell division during vulval organogenesis.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-10074449,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-10454549,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-10952902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-10973053,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-11416209,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-11585906,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-11683916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-11872831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-12408803,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-12459787,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-12482710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-12663651,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-12736204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-14516686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-15247923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-15369677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-15489339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-15649465,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-15749820,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-15964814,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-16122351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-17465684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-18155677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-18511465,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-18724937,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-18757046,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-19104047,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-19104053,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-19108610,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-19141611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-1935914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-1970421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-3753901,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-4366476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-478167,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-6894129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-7770042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-7781065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-8093616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-838129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-8543167,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-8582641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-8632015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-8681378,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-8951077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-9012534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-9521900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-9716524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-9834196,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20005870-9895317
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1095-564X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2009 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
338
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
226-36
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pubmed:dateRevised |
2010-9-27
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pubmed:meshHeading |
pubmed-meshheading:20005870-Animals,
pubmed-meshheading:20005870-Caenorhabditis elegans,
pubmed-meshheading:20005870-Caenorhabditis elegans Proteins,
pubmed-meshheading:20005870-Cell Division,
pubmed-meshheading:20005870-Cell Lineage,
pubmed-meshheading:20005870-Cell Proliferation,
pubmed-meshheading:20005870-Female,
pubmed-meshheading:20005870-Gene Regulatory Networks,
pubmed-meshheading:20005870-Organogenesis,
pubmed-meshheading:20005870-Transcription Factors,
pubmed-meshheading:20005870-Vulva
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pubmed:year |
2010
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pubmed:articleTitle |
C. elegans BED domain transcription factor BED-3 controls lineage-specific cell proliferation during organogenesis.
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pubmed:affiliation |
Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. bchti@nus.edu.sg
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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