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rdf:type |
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lifeskim:mentions |
umls-concept:C0020792,
umls-concept:C0205314,
umls-concept:C0205531,
umls-concept:C0226896,
umls-concept:C0442027,
umls-concept:C0679622,
umls-concept:C0935763,
umls-concept:C1415306,
umls-concept:C1446409,
umls-concept:C1527415,
umls-concept:C1709060
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pubmed:issue |
2
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pubmed:dateCreated |
2010-2-3
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pubmed:abstractText |
The optimisation of an HTS hit series (1) leading to the identification of structurally novel, selective, orally bioavailable mGluR2 positive modulators GSK1331258 and GSK1331268 is described. Structure-activity relationships, attenuation of dopaminergic activity, and potentiation of mGluR2 responses in rat hippocampal MPP-DG synapses are also reported.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:ADLEE HEH,
pubmed-author:BianchiFedericaF,
pubmed-author:BranchCliveC,
pubmed-author:CortiCorradoC,
pubmed-author:D'AlessandroPier LPL,
pubmed-author:GarlandStephen LSL,
pubmed-author:KoppeEmma LEL,
pubmed-author:MontanariDinoD,
pubmed-author:NashDavidD,
pubmed-author:OsborneGregG,
pubmed-author:PerezPalomaP,
pubmed-author:PowneyBenB,
pubmed-author:RochevilleMagalieM,
pubmed-author:RothAdelheidA,
pubmed-author:SavaAnnaA,
pubmed-author:SmithPaul WPW,
pubmed-author:UgoliniAnnarosaA,
pubmed-author:WatsonStephen PSP,
pubmed-author:de la FuenteJesúsJ
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pubmed:copyrightInfo |
Copyright 2009 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
15
|
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pubmed:volume |
20
|
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
759-62
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pubmed:meshHeading |
pubmed-meshheading:20005096-Administration, Oral,
pubmed-meshheading:20005096-Allosteric Regulation,
pubmed-meshheading:20005096-Animals,
pubmed-meshheading:20005096-Benzimidazoles,
pubmed-meshheading:20005096-Dopamine,
pubmed-meshheading:20005096-High-Throughput Screening Assays,
pubmed-meshheading:20005096-Piperazines,
pubmed-meshheading:20005096-Rats,
pubmed-meshheading:20005096-Receptors, Metabotropic Glutamate,
pubmed-meshheading:20005096-Structure-Activity Relationship,
pubmed-meshheading:20005096-Synaptic Potentials
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pubmed:year |
2010
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|
pubmed:articleTitle |
The identification of structurally novel, selective, orally bioavailable positive modulators of mGluR2.
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pubmed:affiliation |
GlaxoSmithKline, Neurosciences Centre of Excellence for Drug Discovery, New Frontiers Science Park, Harlow, UK.
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pubmed:publicationType |
Journal Article
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