Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2010-2-5
pubmed:databankReference
pubmed:abstractText
To elucidate whether tyrosine kinase inhibitor (TKI) resistance in chronic myeloid leukemia is associated with characteristic genomic alterations, we analyzed DNA samples from 45 TKI-resistant chronic myeloid leukemia patients with 250K single nucleotide polymorphism arrays. From 20 patients, matched serial samples of pretreatment and TKI resistance time points were available. Eleven of the 45 TKI-resistant patients had mutations of BCR-ABL1, including 2 T315I mutations. Besides known TKI resistance-associated genomic lesions, such as duplication of the BCR-ABL1 gene (n = 8) and trisomy 8 (n = 3), recurrent submicroscopic alterations, including acquired uniparental disomy, were detectable on chromosomes 1, 8, 9, 17, 19, and 22. On chromosome 22, newly acquired and recurrent deletions of the IGLC1 locus were detected in 3 patients, who had previously presented with lymphoid or myeloid blast crisis. This may support a hypothesis of TKI-induced selection of subclones differentiating into immature B-cell progenitors as a mechanism of disease progression and evasion of TKI sensitivity.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19965645, http://linkedlifedata.com/resource/pubmed/commentcorrection/19965645-11919388, http://linkedlifedata.com/resource/pubmed/commentcorrection/19965645-16024607, http://linkedlifedata.com/resource/pubmed/commentcorrection/19965645-16818283, http://linkedlifedata.com/resource/pubmed/commentcorrection/19965645-16953242, http://linkedlifedata.com/resource/pubmed/commentcorrection/19965645-17133111, http://linkedlifedata.com/resource/pubmed/commentcorrection/19965645-17151364, http://linkedlifedata.com/resource/pubmed/commentcorrection/19965645-17456720, http://linkedlifedata.com/resource/pubmed/commentcorrection/19965645-17564968, http://linkedlifedata.com/resource/pubmed/commentcorrection/19965645-17890455, http://linkedlifedata.com/resource/pubmed/commentcorrection/19965645-18385684, http://linkedlifedata.com/resource/pubmed/commentcorrection/19965645-18408710, http://linkedlifedata.com/resource/pubmed/commentcorrection/19965645-18543309, http://linkedlifedata.com/resource/pubmed/commentcorrection/19965645-18653275, http://linkedlifedata.com/resource/pubmed/commentcorrection/19965645-18668129, http://linkedlifedata.com/resource/pubmed/commentcorrection/19965645-19278963, http://linkedlifedata.com/resource/pubmed/commentcorrection/19965645-19732723, http://linkedlifedata.com/resource/pubmed/commentcorrection/19965645-8535212, http://linkedlifedata.com/resource/pubmed/commentcorrection/19965645-9787180
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1528-0020
pubmed:author
pubmed:issnType
Electronic
pubmed:day
4
pubmed:volume
115
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1049-53
pubmed:dateRevised
2011-7-25
pubmed:meshHeading
pubmed-meshheading:19965645-Humans, pubmed-meshheading:19965645-Thiazoles, pubmed-meshheading:19965645-Pyrimidines, pubmed-meshheading:19965645-Mutation, pubmed-meshheading:19965645-Piperazines, pubmed-meshheading:19965645-Chromosome Aberrations, pubmed-meshheading:19965645-Leukemia, Myelogenous, Chronic, BCR-ABL Positive, pubmed-meshheading:19965645-Protein Kinase Inhibitors, pubmed-meshheading:19965645-Drug Resistance, Neoplasm, pubmed-meshheading:19965645-Chromosomes, Human, Pair 22, pubmed-meshheading:19965645-Chromosomes, Human, Pair 9, pubmed-meshheading:19965645-Chromosomes, Human, Pair 17, pubmed-meshheading:19965645-Chromosomes, Human, Pair 19, pubmed-meshheading:19965645-Chromosomes, Human, Pair 1, pubmed-meshheading:19965645-Protein-Tyrosine Kinases, pubmed-meshheading:19965645-Gene Expression Profiling, pubmed-meshheading:19965645-Chromosomes, Human, Pair 8, pubmed-meshheading:19965645-Fusion Proteins, bcr-abl, pubmed-meshheading:19965645-Gene Expression Regulation, Leukemic
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