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pubmed-article:19958089pubmed:abstractTextCyclophosphamide is a cornerstone in the treatment of many pediatric and adult malignancies, as well as in the treatment of refractory autoimmune conditions. Genetic factors are thought to play a role in the interindividual variation in both response and toxicities associated with cyclophosphamide-based therapies. This drug focus reviews the most compelling studies conducted on the pharmacogenetics of cyclophosphamide-based therapies. Broader pharmacogenomic studies are needed and may reveal additional factors important in susceptibility to toxicity and/or response to therapy.lld:pubmed
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pubmed-article:19958089pubmed:dateRevised2011-9-26lld:pubmed
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pubmed-article:19958089pubmed:articleTitleDrug focus: Pharmacogenetic studies related to cyclophosphamide-based therapy.lld:pubmed
pubmed-article:19958089pubmed:affiliationUniversity of Chicago, 900 East 57th Street, Room 7100, Chicago, IL 60637, USA.lld:pubmed
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