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rdf:type |
|
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lifeskim:mentions |
umls-concept:C0035647,
umls-concept:C0039796,
umls-concept:C0042776,
umls-concept:C0205263,
umls-concept:C0205314,
umls-concept:C0205419,
umls-concept:C0332161,
umls-concept:C0443199,
umls-concept:C0449774,
umls-concept:C0679622,
umls-concept:C1521840,
umls-concept:C1523116
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pubmed:issue |
6
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|
pubmed:dateCreated |
2009-12-2
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|
pubmed:abstractText |
Lassa virus pathogenesis is believed to involve dysregulation of cytokines. We have previously shown nuclear factor-kappaB (NF-kappaB) inhibition using a BSL-2 model for Lassa fever. Here we further define the potential mechanism for NF-kappaB inhibition as involving increased levels of repressive p50/p50 homodimers, and suggest a novel therapeutic strategy that acts via modulation of host signaling.
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pubmed:grant |
|
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
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pubmed:month |
Dec
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pubmed:issn |
1557-8976
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pubmed:author |
|
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pubmed:issnType |
Electronic
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pubmed:volume |
22
|
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pubmed:owner |
NLM
|
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pubmed:authorsComplete |
Y
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pubmed:pagination |
457-62
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:19951183-Animals,
pubmed-meshheading:19951183-Arenaviridae Infections,
pubmed-meshheading:19951183-Defective Viruses,
pubmed-meshheading:19951183-Drug Delivery Systems,
pubmed-meshheading:19951183-Mice,
pubmed-meshheading:19951183-Monocytes,
pubmed-meshheading:19951183-NF-kappa B,
pubmed-meshheading:19951183-NF-kappa B p50 Subunit,
pubmed-meshheading:19951183-Phosphorylation,
pubmed-meshheading:19951183-Pichinde virus,
pubmed-meshheading:19951183-Protein Processing, Post-Translational,
pubmed-meshheading:19951183-Protein Transport,
pubmed-meshheading:19951183-Protein-Tyrosine Kinases,
pubmed-meshheading:19951183-Signal Transduction,
pubmed-meshheading:19951183-Transcription, Genetic,
pubmed-meshheading:19951183-Transcription Factor RelA,
pubmed-meshheading:19951183-Virulence
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|
pubmed:year |
2009
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pubmed:articleTitle |
Attenuated and lethal variants of Pichindé virus induce differential patterns of NF-kappaB activation suggesting a potential target for novel therapeutics.
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pubmed:affiliation |
Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas 77555-0609, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro,
Research Support, N.I.H., Extramural
|
