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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2009-12-16
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pubmed:abstractText |
Interleukin-12 (IL-12) is a pleiotropic cytokine that is elevated in the affected organs of patients with Sjögren's syndrome (SS). We have previously reported that overexpression of IL-12 in CBA mice leads to mononuclear infiltration of salivary and lacrimal glands, as well as to expansion of bronchial lymphoid tissue and decreased mucociliary clearance. Because xerostomia is one of the most important clinical features in SS patients, our main objective in the current study was to evaluate salivary gland function in IL-12-transgenic mice. Our secondary objective was to further characterize this animal model and to determine if the changes observed in these mice are representative of those observed in patients with SS overall.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0004-3591
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3633-41
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pubmed:dateRevised |
2011-3-3
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pubmed:meshHeading |
pubmed-meshheading:19950301-Animals,
pubmed-meshheading:19950301-Antibodies, Antinuclear,
pubmed-meshheading:19950301-Biological Markers,
pubmed-meshheading:19950301-Body Weight,
pubmed-meshheading:19950301-Cell Enlargement,
pubmed-meshheading:19950301-Cell Proliferation,
pubmed-meshheading:19950301-Cholinergic Agents,
pubmed-meshheading:19950301-Disease Models, Animal,
pubmed-meshheading:19950301-Female,
pubmed-meshheading:19950301-Interleukin-12,
pubmed-meshheading:19950301-Lacrimal Apparatus,
pubmed-meshheading:19950301-Leukocytes, Mononuclear,
pubmed-meshheading:19950301-Male,
pubmed-meshheading:19950301-Mice,
pubmed-meshheading:19950301-Mice, Transgenic,
pubmed-meshheading:19950301-Pilocarpine,
pubmed-meshheading:19950301-Salivary Glands,
pubmed-meshheading:19950301-Sex Factors,
pubmed-meshheading:19950301-Sjogren's Syndrome
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pubmed:year |
2009
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pubmed:articleTitle |
Interleukin-12 induces salivary gland dysfunction in transgenic mice, providing a new model of Sjögren's syndrome.
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pubmed:affiliation |
National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Intramural
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