Source:http://linkedlifedata.com/resource/pubmed/id/19950011
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2009-12-1
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| pubmed:abstractText |
After decades of successful clinical use, the exact molecular mechanisms by which the anti-resorptive bisphosphonate drugs (BPs) exert their effects are now being revealed. In addition to their anti-resorptive effects, it is now apparent that nitrogen-containing BPs (N-BPs) have immunomodulatory properties. Specifically, these drugs activate immune cells called gamma, delta T lymphocytes. In this chapter we discuss the mechanism of gamma, delta T cell activation by N-BPs and propose that N-BPs may provide a safe and effective means for manipulating gamma,delta T cell activity in future immunotherapeutic approaches.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
0065-2598
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
658
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
11-20
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| pubmed:meshHeading |
pubmed-meshheading:19950011-Acute-Phase Reaction,
pubmed-meshheading:19950011-Animals,
pubmed-meshheading:19950011-Cell Proliferation,
pubmed-meshheading:19950011-Diphosphonates,
pubmed-meshheading:19950011-Lymphocyte Activation,
pubmed-meshheading:19950011-Mice,
pubmed-meshheading:19950011-Receptors, Antigen, T-Cell, gamma-delta,
pubmed-meshheading:19950011-T-Lymphocytes
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| pubmed:year |
2010
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| pubmed:articleTitle |
Activation of ?? T cells by bisphosphonates.
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| pubmed:affiliation |
Bone and Musculoskeletal Research Programme, Institute of Medical Sciences, University of Aberdeen, Foresterhill, AB25 2ZD, Aberdeen, UK. k.thompson@abdn.ac.uk
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| pubmed:publicationType |
Journal Article
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