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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2010-3-3
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pubmed:abstractText |
When oseltamivir is administered in extremely high doses (500-1000 mg/kg) to young juvenile rats, central nervous system toxicity and death occurred in some animals. Mortality was not observed in older juvenile rats, suggesting a possible relationship between neurotoxicity and an immature blood-brain barrier. To assess potential neurologic adverse effects of oseltamivir use in infants, a retrospective chart review was performed in infants less than 12 months of age who received oseltamivir, amantadine, or rimantadine.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1532-0987
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pubmed:author |
pubmed-author:AbughaliNazhaN,
pubmed-author:AbzugMark JMJ,
pubmed-author:BradleyJohn SJS,
pubmed-author:CloudGretchen AGA,
pubmed-author:EnglundJanetJ,
pubmed-author:GriffinJillJ,
pubmed-author:Guzman-CottrillJudithJ,
pubmed-author:JacobsRichard FRF,
pubmed-author:JesterPennyP,
pubmed-author:KimberlinDavid WDW,
pubmed-author:LangDavidD,
pubmed-author:LeachCharlesC,
pubmed-author:NIAID Collaborative Antiviral Study Group,
pubmed-author:RamiloOctavioO,
pubmed-author:RobinsonJoanJ,
pubmed-author:RomeroJosé RJR,
pubmed-author:ShalabiMarwanM,
pubmed-author:SheltonMarkM,
pubmed-author:StorchGregoryG,
pubmed-author:WadeKelly CKC,
pubmed-author:WhitleyRichard JRJ
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pubmed:issnType |
Electronic
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
195-8
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pubmed:dateRevised |
2010-6-28
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pubmed:meshHeading |
pubmed-meshheading:19949363-Adamantane,
pubmed-meshheading:19949363-Antiviral Agents,
pubmed-meshheading:19949363-Central Nervous System,
pubmed-meshheading:19949363-Female,
pubmed-meshheading:19949363-Humans,
pubmed-meshheading:19949363-Infant,
pubmed-meshheading:19949363-Infant, Newborn,
pubmed-meshheading:19949363-Influenza, Human,
pubmed-meshheading:19949363-Male,
pubmed-meshheading:19949363-Nervous System Diseases,
pubmed-meshheading:19949363-Oseltamivir,
pubmed-meshheading:19949363-Retrospective Studies,
pubmed-meshheading:19949363-Rimantadine
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pubmed:year |
2010
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pubmed:articleTitle |
Safety of oseltamivir compared with the adamantanes in children less than 12 months of age.
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pubmed:affiliation |
Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Alabama, Birmingham, Birmingham, AL 35233, USA. dkimberlin@peds.uab.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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