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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
22
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pubmed:dateCreated |
2009-11-26
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pubmed:databankReference |
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pubmed:abstractText |
The immunopathogenesis of type 1 diabetes mellitus is associated with T-lymphocyte autoimmunity. However, there is growing evidence that B lymphocytes play a role in many T-lymphocyte-mediated diseases. It is possible to achieve selective depletion of B lymphocytes with rituximab, an anti-CD20 monoclonal antibody. This phase 2 study evaluated the role of B-lymphocyte depletion in patients with type 1 diabetes.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1533-4406
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pubmed:author |
pubmed-author:BeckerDorothy JDJ,
pubmed-author:GitelmanStephen ESE,
pubmed-author:GolandRobinR,
pubmed-author:GottliebPeter APA,
pubmed-author:GreenbaumCarla JCJ,
pubmed-author:Krause-SteinraufHeidiH,
pubmed-author:LachinJohn MJM,
pubmed-author:MarksJennifer BJB,
pubmed-author:McGeePaula FPF,
pubmed-author:MoranAntoinette MAM,
pubmed-author:PescovitzMark DMD,
pubmed-author:RaskinPhilipP,
pubmed-author:RodriguezHenryH,
pubmed-author:SchatzDesmond ADA,
pubmed-author:SkylerJay SJS,
pubmed-author:Type 1 Diabetes TrialNet Anti-CD20 Study Group,
pubmed-author:WherrettDianeD,
pubmed-author:WilsonDarrell MDM
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pubmed:copyrightInfo |
2009 Massachusetts Medical Society
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pubmed:issnType |
Electronic
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pubmed:day |
26
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pubmed:volume |
361
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2143-52
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:19940299-Adolescent,
pubmed-meshheading:19940299-Adult,
pubmed-meshheading:19940299-Antibodies, Monoclonal,
pubmed-meshheading:19940299-Antibodies, Monoclonal, Murine-Derived,
pubmed-meshheading:19940299-Area Under Curve,
pubmed-meshheading:19940299-B-Lymphocytes,
pubmed-meshheading:19940299-C-Peptide,
pubmed-meshheading:19940299-Child,
pubmed-meshheading:19940299-Diabetes Mellitus, Type 1,
pubmed-meshheading:19940299-Double-Blind Method,
pubmed-meshheading:19940299-Female,
pubmed-meshheading:19940299-Hemoglobin A, Glycosylated,
pubmed-meshheading:19940299-Humans,
pubmed-meshheading:19940299-Immunoglobulin M,
pubmed-meshheading:19940299-Immunologic Factors,
pubmed-meshheading:19940299-Insulin-Secreting Cells,
pubmed-meshheading:19940299-Male,
pubmed-meshheading:19940299-Young Adult
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pubmed:year |
2009
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pubmed:articleTitle |
Rituximab, B-lymphocyte depletion, and preservation of beta-cell function.
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pubmed:affiliation |
Indiana University School of Medicine, Indianapolis, USA.
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study,
Research Support, N.I.H., Extramural
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