| pubmed-article:19934290 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19934290 | lifeskim:mentions | umls-concept:C0008976 | lld:lifeskim |
| pubmed-article:19934290 | lifeskim:mentions | umls-concept:C1516238 | lld:lifeskim |
| pubmed-article:19934290 | lifeskim:mentions | umls-concept:C0278480 | lld:lifeskim |
| pubmed-article:19934290 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:19934290 | lifeskim:mentions | umls-concept:C1274040 | lld:lifeskim |
| pubmed-article:19934290 | lifeskim:mentions | umls-concept:C1537502 | lld:lifeskim |
| pubmed-article:19934290 | lifeskim:mentions | umls-concept:C0205210 | lld:lifeskim |
| pubmed-article:19934290 | pubmed:issue | 23 | lld:pubmed |
| pubmed-article:19934290 | pubmed:dateCreated | 2009-12-2 | lld:pubmed |
| pubmed-article:19934290 | pubmed:abstractText | Alterations in the RAS and RAF pathway relate to epigenetic and epigenomic aberrations, and are important in colorectal carcinogenesis. KRAS mutation in metastatic colorectal cancer predicts resistance to anti-epidermal growth factor receptor (EGFR)-targeted therapy (cetuximab or panitumumab). It remains uncertain, however, whether KRAS mutation predicts prognosis or clinical outcome of colon cancer patients independent of anti-EGFR therapy. Methods: We conducted a study of 508 cases identified among 1,264 patients with stage III colon cancer who enrolled in a randomized adjuvant chemotherapy trial (5-fluorouracil, leucovorin with or without irinotecan) in 1999-2001 (CALGB 89803). KRAS mutations were detected in 178 tumors (35%) by pyrosequencing. Kaplan-Meier and Cox proportional hazard models assessed the prognostic significance of KRAS mutation and adjusted for potential confounders including age, sex, tumor location, tumor/node stage, performance status, adjuvant chemotherapy arm, and microsatellite instability status. | lld:pubmed |
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| pubmed-article:19934290 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19934290 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19934290 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19934290 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19934290 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19934290 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:19934290 | pubmed:issn | 1078-0432 | lld:pubmed |
| pubmed-article:19934290 | pubmed:author | pubmed-author:Cancer and... | lld:pubmed |
| pubmed-article:19934290 | pubmed:author | pubmed-author:North... | lld:pubmed |
| pubmed-article:19934290 | pubmed:author | pubmed-author:Southwest... | lld:pubmed |
| pubmed-article:19934290 | pubmed:author | pubmed-author:HollisDonnaD | lld:pubmed |
| pubmed-article:19934290 | pubmed:author | pubmed-author:MayerRobert... | lld:pubmed |
| pubmed-article:19934290 | pubmed:author | pubmed-author:FuchsCharles... | lld:pubmed |
| pubmed-article:19934290 | pubmed:author | pubmed-author:OginoShujiS | lld:pubmed |
| pubmed-article:19934290 | pubmed:author | pubmed-author:NiedzwieckiDo... | lld:pubmed |
| pubmed-article:19934290 | pubmed:author | pubmed-author:BertagnolliMo... | lld:pubmed |
| pubmed-article:19934290 | pubmed:author | pubmed-author:GoldbergRicha... | lld:pubmed |
| pubmed-article:19934290 | pubmed:author | pubmed-author:SaltzLeonard... | lld:pubmed |
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| pubmed-article:19934290 | pubmed:author | pubmed-author:SchaeferPaulP | lld:pubmed |
| pubmed-article:19934290 | pubmed:author | pubmed-author:IraharaNatsum... | lld:pubmed |
| pubmed-article:19934290 | pubmed:author | pubmed-author:Canadian... | lld:pubmed |
| pubmed-article:19934290 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:19934290 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:19934290 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:19934290 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19934290 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19934290 | pubmed:pagination | 7322-9 | lld:pubmed |
| pubmed-article:19934290 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
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| pubmed-article:19934290 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19934290 | pubmed:articleTitle | KRAS mutation in stage III colon cancer and clinical outcome following intergroup trial CALGB 89803. | lld:pubmed |
| pubmed-article:19934290 | pubmed:affiliation | Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA. shuji_ogino@dfci.harvard.edu | lld:pubmed |
| pubmed-article:19934290 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19934290 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| pubmed-article:19934290 | pubmed:publicationType | Multicenter Study | lld:pubmed |
| pubmed-article:19934290 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:3845 | entrezgene:pubmed | pubmed-article:19934290 | lld:entrezgene |
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