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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
49
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pubmed:dateCreated |
2010-8-17
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pubmed:abstractText |
Both activated and resting CD4(+) T cells in mucosal tissues play important roles in the earliest phases of infection after sexual transmission of HIV-1, a process that is inefficient. HIV-1 gp120 binds to integrin alpha(4)beta(7) (alpha(4)beta(7)), the gut mucosal homing receptor. We find that alpha(4)beta(7)(high) CD4(+) T cells are more susceptible to productive infection than are alpha(4)beta(7)(low-neg) CD4(+) T cells in part because this cellular subset is enriched with metabolically active CD4(+) T cells. alpha(4)beta(7)(high) CD4(+) T cells are CCR5(high) and CXCR4(low); on these cells, alpha(4)beta(7) appears in a complex with CD4. The specific affinity of gp120 for alpha(4)beta(7) provides a mechanism for HIV-1 to target activated cells that are critical for efficient virus propagation and dissemination following sexual transmission.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19933330-10099122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19933330-10992458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19933330-11018170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19933330-11188697,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19933330-11698309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19933330-11728332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19933330-14645084,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19933330-15044802,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19933330-15064398,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19933330-15365095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19933330-15485623,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19933330-15485630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19933330-15793562,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19933330-15809897,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19933330-16200081,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19933330-16227291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19933330-16482171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19933330-17065209,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19933330-17306567,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19933330-17314521,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19933330-18264102,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19933330-18668044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19933330-19149993,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19933330-19165325,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19933330-19571800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19933330-2541915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19933330-7542550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19933330-8684468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19933330-8709276,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19933330-9168119
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1091-6490
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pubmed:author |
pubmed-author:ArthosJamesJ,
pubmed-author:CicalaClaudiaC,
pubmed-author:FauciAnthony SAS,
pubmed-author:GoodeDiana JDJ,
pubmed-author:GopaulRavindraR,
pubmed-author:HiattJosephJ,
pubmed-author:IzullaPresonP,
pubmed-author:JelicicKatijaK,
pubmed-author:KaulRupertR,
pubmed-author:KimaniJoshuaJ,
pubmed-author:KottililShyamasundaranS,
pubmed-author:MacleodKatilynK,
pubmed-author:MartinelliElenaE,
pubmed-author:McKinnonLyleL,
pubmed-author:McNallyJonathan PJP,
pubmed-author:O'SheaAngelineA,
pubmed-author:PascuccioMassimilianoM,
pubmed-author:PatelNikitaN,
pubmed-author:Van RykDonaldD,
pubmed-author:WeiDanlanD,
pubmed-author:YiLingL
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pubmed:issnType |
Electronic
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pubmed:day |
8
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pubmed:volume |
106
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
20877-82
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pubmed:dateRevised |
2010-9-27
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pubmed:meshHeading |
pubmed-meshheading:19933330-Antibodies, Monoclonal,
pubmed-meshheading:19933330-Antigens, CD4,
pubmed-meshheading:19933330-CD4-Positive T-Lymphocytes,
pubmed-meshheading:19933330-Cell Membrane,
pubmed-meshheading:19933330-Female,
pubmed-meshheading:19933330-Genitalia, Female,
pubmed-meshheading:19933330-HIV Infections,
pubmed-meshheading:19933330-HIV-1,
pubmed-meshheading:19933330-Humans,
pubmed-meshheading:19933330-Immunoprecipitation,
pubmed-meshheading:19933330-Integrins,
pubmed-meshheading:19933330-Intestinal Mucosa,
pubmed-meshheading:19933330-Lymphocyte Activation,
pubmed-meshheading:19933330-Receptors, CCR5,
pubmed-meshheading:19933330-T-Lymphocyte Subsets,
pubmed-meshheading:19933330-Virus Replication
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pubmed:year |
2009
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pubmed:articleTitle |
The integrin alpha4beta7 forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1.
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