Source:http://linkedlifedata.com/resource/pubmed/id/19929890
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2010-5-14
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| pubmed:abstractText |
Currently radiologists have the option of subcategorizing BI-RADS 4 breast lesions into 4A (low suspicion for malignancy), 4B (intermediate suspicion of malignancy), and 4C (moderate concern, but not classic for malignancy). To determine the clinical significance of BI-RADS 4 subcategories and the common pathologic changes associated with these mammographic lesions, a retrospective review of 239 consecutive stereotactic-needle core biopsies (SNCB) for microcalcifications was performed. All 239 SNCBs were BI-RADS 4 lesions, and of these, 191 were subcategorized to 4A, 4B or 4C. Ninety-four of 191 (49%) were 4A, 73 (38%) were 4B, and 24 (13%) were 4C. Fibrocystic change was the most common finding (66/239; 28%) followed by ductal carcinoma in situ (DCIS) accounting for 23% of cases. This was followed by columnar cell alteration with or without atypia (47/239; 19%), and fibroadenoma (45/239; 19%). While 70% (17/24) of BI-RADS 4C category lesions were DCIS, only 21% (15/73) of BI-RADS 4B and 10% (10/94) of BI-RADS 4A were DCIS. Without sub-categorization, carcinoma was diagnosed in 23% (55/239) of all cases with BI-RADS 4. Therefore, subcategorizing BI-RADS 4 lesions is important since it not only benefits the patient and clinician in understanding the level of concern for carcinoma, but will also alert the pathologist.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:issn |
1524-4741
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
16
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
28-31
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| pubmed:dateRevised |
2010-11-29
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| pubmed:meshHeading |
pubmed-meshheading:19929890-Adult,
pubmed-meshheading:19929890-Aged,
pubmed-meshheading:19929890-Aged, 80 and over,
pubmed-meshheading:19929890-Biopsy, Fine-Needle,
pubmed-meshheading:19929890-Breast Neoplasms,
pubmed-meshheading:19929890-Calcinosis,
pubmed-meshheading:19929890-Cohort Studies,
pubmed-meshheading:19929890-Combined Modality Therapy,
pubmed-meshheading:19929890-Female,
pubmed-meshheading:19929890-Humans,
pubmed-meshheading:19929890-Immunohistochemistry,
pubmed-meshheading:19929890-Mammography,
pubmed-meshheading:19929890-Middle Aged,
pubmed-meshheading:19929890-Neoplasm Staging,
pubmed-meshheading:19929890-Predictive Value of Tests,
pubmed-meshheading:19929890-Prognosis,
pubmed-meshheading:19929890-Risk Assessment,
pubmed-meshheading:19929890-Sensitivity and Specificity,
pubmed-meshheading:19929890-Stereotaxic Techniques,
pubmed-meshheading:19929890-Survival Analysis,
pubmed-meshheading:19929890-Treatment Outcome
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| pubmed:articleTitle |
Clinical implications of subcategorizing BI-RADS 4 breast lesions associated with microcalcification: a radiology-pathology correlation study.
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| pubmed:affiliation |
Department of Pathology, University of Louisville, Louisville, Kentucky 40202, USA.
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| pubmed:publicationType |
Journal Article,
Comparative Study
|