Source:http://linkedlifedata.com/resource/pubmed/id/19929794
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
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| pubmed:dateCreated |
2009-11-25
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| pubmed:abstractText |
We designed a multicenter cross-sectional study to describe the epidemiological characteristics of the HIV-1-infected population aged 70 years or more in our setting. 179 individuals from eight university hospitals in Barcelona, Spain, were included, representing 1.5% of HIV-1 infected subjects followed during 2008. Most subjects were male (76%) and had acquired HIV infection through sexual intercourse (87%); 69% had been diagnosed with HIV-1 after their sixties. The CD4 cell counts at HIV-1 diagnosis were < 200 cells/mm(3) in 52% of individuals, whereas this was only seen in 34% of subjects from a published cohort including younger HIV- infected adults from the same setting [1]. Most of our patients were on HAART, had undetectable HIV-1 viremia and the most recent median CD4 cell counts were >or= 350 cells/mm(3). 154 subjects had at least one comorbid condition, including dyslipidemia (54%), hypertension (36%), hyperglycemia or diabetes (30%), cardiovascular disease (23%), chronic renal failure (18%), history of neoplasia (17%) and cognitive impairment (11%). Lipodystrophy was reported in 58% of individuals. Rates of hypercholesterolemia, diabetes and cancer were higher than those reported in unselected local population (28%, 17% and 7%, respectively). The study participants were taking an average of 2.97 drugs (range 1-10) other than antiretrovirals. In conclusion, the elder population infected with HIV-1 is likely being diagnosed late and at lower CD4+ counts and is frequently affected by comorbidities and co-medication. Based on our findings, we suggest some recommendations regarding the management of this growing population.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
1873-4251
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| pubmed:author |
pubmed-author:ClotetBonaventuraB,
pubmed-author:CurranAdrianA,
pubmed-author:DalmauDavidD,
pubmed-author:DomingoPereP,
pubmed-author:GatellJose MariaJM,
pubmed-author:MoltóJoséJ,
pubmed-author:MotheBeatrizB,
pubmed-author:NegredoEugeniaE,
pubmed-author:ParedesRogerR,
pubmed-author:PedrolEnriqueE,
pubmed-author:Perez-AlvarezNúriaN,
pubmed-author:PerezIñakiI,
pubmed-author:PodzamczerDanielD,
pubmed-author:RiberaEstebanE,
pubmed-author:VidalFrancescF,
pubmed-author:ViladésConsueloC
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| pubmed:issnType |
Electronic
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| pubmed:volume |
7
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
597-600
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| pubmed:meshHeading |
pubmed-meshheading:19929794-Age Factors,
pubmed-meshheading:19929794-Aged,
pubmed-meshheading:19929794-Aged, 80 and over,
pubmed-meshheading:19929794-Antiretroviral Therapy, Highly Active,
pubmed-meshheading:19929794-CD4 Lymphocyte Count,
pubmed-meshheading:19929794-Cognition Disorders,
pubmed-meshheading:19929794-Comorbidity,
pubmed-meshheading:19929794-Cross-Sectional Studies,
pubmed-meshheading:19929794-Dyslipidemias,
pubmed-meshheading:19929794-Female,
pubmed-meshheading:19929794-Glucose Metabolism Disorders,
pubmed-meshheading:19929794-HIV Infections,
pubmed-meshheading:19929794-HIV-1,
pubmed-meshheading:19929794-Humans,
pubmed-meshheading:19929794-Hypertension,
pubmed-meshheading:19929794-Kidney Failure, Chronic,
pubmed-meshheading:19929794-Male,
pubmed-meshheading:19929794-Sex Factors,
pubmed-meshheading:19929794-Spain,
pubmed-meshheading:19929794-Vascular Diseases
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| pubmed:year |
2009
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| pubmed:articleTitle |
HIV-1 infection in subjects older than 70: a multicenter cross-sectional assessment in Catalonia, Spain.
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| pubmed:affiliation |
Lluita contra la Sida' Foundation, Hospital Universitari Germans Trias i Pujol, Catalonia, Spain.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study
|