Linked Life Data

19926458

Source:http://linkedlifedata.com/resource/pubmed/id/19926458

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-2-3
pubmed:abstractText
Chitosan-coated nano-size liposomes as a new carrier with bioactivity were made from phosphatidylcholine (pc) and cholesterol (chol) by direct injection. Liposomes prepared using ethanol as a solvent with pc:chol ratios of 40:60 and 60:40 displayed mall mean diameters (97.4nm and 95.8nm, respectively). Different factors affecting the loading efficiency and payload of Vitamin C for these nano-size liposomes were investigated by high-pressure liquid chromatography. Liposomes prepared with a pc:chol ratio of 60:40 were promising Vitamin C carriers with a maximum loading efficiency about 96.5% and payload about 46.82%. When liposomes were prepared with 100mg initial mass of Vitamin C, maximum loading efficiency was obtained. Furthermore, with an increasing initial mass of Vitamin C, the payload increased. Based on the experimental results, it appears that the chitosan concentration does not affect the loading efficiency and payload of liposomes. Liposomes prepared under the above optimum conditions were stable during 15 weeks storage such that over 85% Vitamin C was protected against oxidation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1873-4367
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
76
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
16-9
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Factors effect on the loading efficiency of Vitamin C loaded chitosan-coated nanoliposomes.
pubmed:affiliation
Graduate School of Biotechnology, Korea University, Seoul, South Korea.
pubmed:publicationType
Journal Article