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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2010-1-21
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pubmed:abstractText |
Atherosclerosis contributes to disruption of neuronal signaling pathways by producing lipid-dependent modifications of brain plasma membranes, neuroinflammation and oxidative stress. We investigated whether long-term (11 weeks) consumption of refined- (ROO) and pomace- (POO) olive oil modulated the fatty acid composition and the levels of membrane signaling proteins in the brain of apolipoprotein E (apoE) knockout (KO) mice, an animal model of atherosclerosis. Both of these oils are rich in bioactive molecules with anti-inflammatory and antioxidant effects. ROO and POO long-term consumption increased the proportion of monounsaturated fatty acids (MUFAs), particularly of oleic acid, while reducing the level of the saturated fatty acids (SFAs) palmitic and stearic acid. As a result, the MUFA:SFA ratio was higher in apoE KO mice brain fed with ROO and POO. Furthermore, both oils reduced the level of arachidonic and eicosapentaenoic acid, suggesting a decrease in the generation of pro- and anti-inflammatory eicosanoids. Finally, ROO and POO induced an increase in the density of membrane proteins implicated in both the Galphas/PKA and Galphaq/PLCbeta1/PKCalpha signaling pathways. The combined effects of long-term ROO and POO consumption on fatty acid composition and the level of signaling proteins involved in PKA and PKC activation, suggest positive effects on neuroinflammation and brain function in apoE KO mice brain, and convert these oils into promising functional foods in diseases involving apoE deficiency.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins E,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP-Dependent Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP-Dependent Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP-Dependent Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Dietary Fats, Unsaturated,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids,
http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Protein alpha...,
http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Protein alpha...,
http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Protein alpha...,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Phospholipase C beta,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Oils,
http://linkedlifedata.com/resource/pubmed/chemical/Plcb1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/olive oil
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1558-9307
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
45
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
53-61
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pubmed:meshHeading |
pubmed-meshheading:19924462-Animals,
pubmed-meshheading:19924462-Apolipoproteins E,
pubmed-meshheading:19924462-Brain,
pubmed-meshheading:19924462-Brain Chemistry,
pubmed-meshheading:19924462-Cyclic AMP-Dependent Protein Kinase RIIalpha Subunit,
pubmed-meshheading:19924462-Cyclic AMP-Dependent Protein Kinase RIIbeta Subunit,
pubmed-meshheading:19924462-Cyclic AMP-Dependent Protein Kinases,
pubmed-meshheading:19924462-Dietary Fats, Unsaturated,
pubmed-meshheading:19924462-Fatty Acids,
pubmed-meshheading:19924462-GTP-Binding Protein alpha Subunits, Gi-Go,
pubmed-meshheading:19924462-GTP-Binding Protein alpha Subunits, Gq-G11,
pubmed-meshheading:19924462-GTP-Binding Protein alpha Subunits, Gs,
pubmed-meshheading:19924462-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:19924462-Male,
pubmed-meshheading:19924462-Mice,
pubmed-meshheading:19924462-Mice, Knockout,
pubmed-meshheading:19924462-Phospholipase C beta,
pubmed-meshheading:19924462-Plant Oils,
pubmed-meshheading:19924462-Protein Kinase C-alpha
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pubmed:year |
2010
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pubmed:articleTitle |
Olive oils modulate fatty acid content and signaling protein expression in apolipoprotein E knockout mice brain.
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pubmed:affiliation |
Section of Cell Biology, Department of Biology, Institut Universitari d'Investigacions en Ciències de la Salut (IUNICS), University of the Balearic Islands, Ctra. Valldemossa Km 7.5, 07122 Palma de Mallorca, Spain. regina.alemany@uib.es
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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