| pubmed-article:19923429 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19923429 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:19923429 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:19923429 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:19923429 | pubmed:issue | 48 | lld:pubmed |
| pubmed-article:19923429 | pubmed:dateCreated | 2009-12-3 | lld:pubmed |
| pubmed-article:19923429 | pubmed:abstractText | We examined how remote enhancers establish physical communication with target promoters to activate gene transcription in response to environmental signals. Although the natural IFN-beta enhancer is located immediately upstream of the core promoter, it also can function as a classical enhancer element conferring virus infection-dependent activation of heterologous promoters, even when it is placed several kilobases away from these promoters. We demonstrated that the remote IFN-beta enhancer "loops out" the intervening DNA to reach the target promoter. These chromatin loops depend on sequence-specific transcription factors bound to the enhancer and the promoter and thus can explain the specificity observed in enhancer-promoter interactions, especially in complex genetic loci. Transcription factor binding sites scattered between an enhancer and a promoter can work as decoys trapping the enhancer in nonproductive loops, thus resembling insulator elements. Finally, replacement of the transcription factor binding sites involved in DNA looping with those of a heterologous prokaryotic protein, the lambda repressor, which is capable of loop formation, rescues enhancer function from a distance by re-establishing enhancer-promoter loop formation. | lld:pubmed |
| pubmed-article:19923429 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19923429 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19923429 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19923429 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19923429 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19923429 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19923429 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19923429 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19923429 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19923429 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19923429 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19923429 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19923429 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19923429 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19923429 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19923429 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19923429 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19923429 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19923429 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19923429 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19923429 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19923429 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19923429 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19923429 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19923429 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19923429 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19923429 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19923429 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19923429 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19923429 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19923429 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19923429 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19923429 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19923429 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19923429 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19923429 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19923429 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19923429 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19923429 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19923429 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19923429 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19923429 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:19923429 | pubmed:issn | 1091-6490 | lld:pubmed |
| pubmed-article:19923429 | pubmed:author | pubmed-author:LomvardasStav... | lld:pubmed |
| pubmed-article:19923429 | pubmed:author | pubmed-author:ThanosDimitri... | lld:pubmed |
| pubmed-article:19923429 | pubmed:author | pubmed-author:McKayDaniel... | lld:pubmed |
| pubmed-article:19923429 | pubmed:author | pubmed-author:MerikaMenieM | lld:pubmed |
| pubmed-article:19923429 | pubmed:author | pubmed-author:NolisIlias... | lld:pubmed |
| pubmed-article:19923429 | pubmed:author | pubmed-author:MantouvalouEv... | lld:pubmed |
| pubmed-article:19923429 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19923429 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:19923429 | pubmed:volume | 106 | lld:pubmed |
| pubmed-article:19923429 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19923429 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19923429 | pubmed:pagination | 20222-7 | lld:pubmed |
| pubmed-article:19923429 | pubmed:dateRevised | 2010-9-28 | lld:pubmed |
| pubmed-article:19923429 | pubmed:meshHeading | pubmed-meshheading:19923429... | lld:pubmed |
| pubmed-article:19923429 | pubmed:meshHeading | pubmed-meshheading:19923429... | lld:pubmed |
| pubmed-article:19923429 | pubmed:meshHeading | pubmed-meshheading:19923429... | lld:pubmed |
| pubmed-article:19923429 | pubmed:meshHeading | pubmed-meshheading:19923429... | lld:pubmed |
| pubmed-article:19923429 | pubmed:meshHeading | pubmed-meshheading:19923429... | lld:pubmed |
| pubmed-article:19923429 | pubmed:meshHeading | pubmed-meshheading:19923429... | lld:pubmed |
| pubmed-article:19923429 | pubmed:meshHeading | pubmed-meshheading:19923429... | lld:pubmed |
| pubmed-article:19923429 | pubmed:meshHeading | pubmed-meshheading:19923429... | lld:pubmed |
| pubmed-article:19923429 | pubmed:meshHeading | pubmed-meshheading:19923429... | lld:pubmed |
| pubmed-article:19923429 | pubmed:meshHeading | pubmed-meshheading:19923429... | lld:pubmed |
| pubmed-article:19923429 | pubmed:meshHeading | pubmed-meshheading:19923429... | lld:pubmed |
| pubmed-article:19923429 | pubmed:meshHeading | pubmed-meshheading:19923429... | lld:pubmed |
| pubmed-article:19923429 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19923429 | pubmed:articleTitle | Transcription factors mediate long-range enhancer-promoter interactions. | lld:pubmed |
| pubmed-article:19923429 | pubmed:affiliation | Institute of Molecular Biology, Genetics and Biotechnology, Biomedical Research Foundation, Academy of Athens, 4 Soranou Efesiou Street, Athens 11527 Greece. | lld:pubmed |
| pubmed-article:19923429 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19923429 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19923429 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19923429 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19923429 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19923429 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19923429 | lld:pubmed |
