Linked Life Data

19918769

Source:http://linkedlifedata.com/resource/pubmed/id/19918769

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2010-3-30
pubmed:abstractText
Precise force regulation is fundamentally important for extraocular muscle (EOM) function. Insulin-like growth factor-1 (IGF-1) plays a major role in EOM force regulation, but the source of endogenous IGF-1 is unclear. Multiple IGF-1 sources may supply EOMs, including: the EOM itself; the systemic circulation; innervating motoneurons; and Schwann cells within nerves. IGF-1 expression was measured in chicken during oculomotor system maturation by using real-time polymerase chain reaction (PCR). Accumulation of radiolabeled IGF-1 in EOMs was compared after either injection into the vascular circulation or into the trochlear nerve. Schwann cells were the most prominent IGF-1 source. A microtubule-dependent mechanism exists to anterogradely transport IGF-1 to EOMs. EOMs were significantly more efficient in extracting IGF-1 from the nerve than from the systemic circulation. Therefore, Schwann cells are the most prominent and potentially the most important source of IGF-1 for EOMs. These findings may contribute to a better understanding of EOM force regulation and its failure in strabismus.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1097-4598
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
478-86
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Schwann cells as a source of insulin-like growth factor-1 for extraocular muscles.
pubmed:affiliation
Department of Physiology and Cell Biology, Mailstop 352, University of Nevada School of Medicine, Reno, Nevada 89557, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural