Linked Life Data

1991558

Source:http://linkedlifedata.com/resource/pubmed/id/1991558

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1991-3-14
pubmed:abstractText
Embryos receiving either the Thp or the twLub2 mutation from their mother die during gestation. In contrast, heterozygous embryos receiving the mutant chromosome from the father are completely viable. In both Thp and twLub2 mutants, one chromosome 17 carries a deletion, which suggests the existence of a discrete maternal lethality effect locus (Tme). In the region whose deletion is responsible for the Thp or twLub2 mutation, a single gene has been cloned so far, the Tcp-1 gene. In the present study, we examined the expression of Tcp-1 gene in mutant embryos carrying either a maternal or a paternal Thp chromosome to test whether this gene could be involved in the Tme effect. We found that the levels of Tcp-1-specific transcripts were similar in both mutant embryos from reciprocal crosses and corresponded to half the levels found in the normal littermates. In addition, the paternal and maternal Tcp-1 alleles had identical methylation patterns. These results indicate that Tcp-1 is not responsible for the maternal lethality effect, and therefore is not located at the Tme locus.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0012-1606
pubmed:author
pubmed:issnType
Print
pubmed:volume
143
pubmed:geneSymbol
T<up>hp</up>, Tcp-1, Tme
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
374-7
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Tcp-1 gene is not responsible for the maternal lethality effect of Thp mutation in mice.
pubmed:affiliation
Institut Jacques Monod, INSERM U 257, Paris, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't