| pubmed-article:19915487 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19915487 | lifeskim:mentions | umls-concept:C0538091 | lld:lifeskim |
| pubmed-article:19915487 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:19915487 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:19915487 | lifeskim:mentions | umls-concept:C0085151 | lld:lifeskim |
| pubmed-article:19915487 | lifeskim:mentions | umls-concept:C0872078 | lld:lifeskim |
| pubmed-article:19915487 | lifeskim:mentions | umls-concept:C0276496 | lld:lifeskim |
| pubmed-article:19915487 | lifeskim:mentions | umls-concept:C0206243 | lld:lifeskim |
| pubmed-article:19915487 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:19915487 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:19915487 | pubmed:dateCreated | 2009-11-26 | lld:pubmed |
| pubmed-article:19915487 | pubmed:abstractText | We previously demonstrated the activation of caspase-6 (Casp-6) in the hippocampus and cortex in cases of mild, moderate, severe, and very severe Alzheimer disease (AD). To determine whether Casp-6 is also activated in familial AD, we performed an immunohistochemical analysis of active Casp-6 and Tau cleaved by Casp-6 in temporal cortex and hippocampal tissue sections from cases of familial AD. The cases included 5 carrying the amyloid precursor protein K670N and M671L Swedish mutation, 1 carrying the amyloid precursor protein E693G Arctic mutation, 2 each carrying the Presenilin I M146V, F105L, A431E, V261F, and Y115C mutations, and 1 with the Presenilin II N141I mutation. Active Casp-6 immunoreactivity was found in all cases. Caspase-6 immunoreactivity was observed in neuritic plaques or in some cases cotton-wool plaques, and in neuropil threads and neurofibrillary tangles. These results indicate that Casp-6 is activated in familial forms of AD, as previously observed in sporadic forms. Because sporadic and familial AD cases have similar pathological features, these results support a fundamental role of Casp-6 in the pathophysiology of both familial and sporadic AD. | lld:pubmed |
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| pubmed-article:19915487 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19915487 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19915487 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19915487 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19915487 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:19915487 | pubmed:issn | 0022-3069 | lld:pubmed |
| pubmed-article:19915487 | pubmed:author | pubmed-author:AlbrechtSteff... | lld:pubmed |
| pubmed-article:19915487 | pubmed:author | pubmed-author:WinbladBengtB | lld:pubmed |
| pubmed-article:19915487 | pubmed:author | pubmed-author:BogdanovicNen... | lld:pubmed |
| pubmed-article:19915487 | pubmed:author | pubmed-author:GhettiBernard... | lld:pubmed |
| pubmed-article:19915487 | pubmed:author | pubmed-author:LeBlancAndréa... | lld:pubmed |
| pubmed-article:19915487 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:19915487 | pubmed:volume | 68 | lld:pubmed |
| pubmed-article:19915487 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19915487 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19915487 | pubmed:pagination | 1282-93 | lld:pubmed |
| pubmed-article:19915487 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
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| pubmed-article:19915487 | pubmed:meshHeading | pubmed-meshheading:19915487... | lld:pubmed |
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| pubmed-article:19915487 | pubmed:meshHeading | pubmed-meshheading:19915487... | lld:pubmed |
| pubmed-article:19915487 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19915487 | pubmed:articleTitle | Caspase-6 activation in familial alzheimer disease brains carrying amyloid precursor protein or presenilin i or presenilin II mutations. | lld:pubmed |
| pubmed-article:19915487 | pubmed:affiliation | Department of Pathology, McGill University, Montréal Children's Hospital, Montréal, Quebec, Canada. | lld:pubmed |
| pubmed-article:19915487 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19915487 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:19915487 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:839 | entrezgene:pubmed | pubmed-article:19915487 | lld:entrezgene |
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